The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Effect of iron chelation therapy on EPO-STAT5 signalling pathway and EPO resistance in iron-overloaded low-risk myelodysplastic syndrome patients
Open accessAbstract
Objectives: Background/aims: We aim to explore low-risk MDS patients’ ESA response and the difference between iron-overloaded (IO) group and the control group in the expression of SOCS1, STAT5 and BCL2L1 which play a key role to EPO-STAT5 signal pathway.Methods: 56 low-risk MDS patients were divided into experimental group, IO patients; control group, non-IO patients. Among experimental group, 28 IO patients were treated with iron chelation therapy (ICT). SOCS1, phosphorylated STAT5 (p-STAT5) and BCL2L1 protein concentration in bone marrow supernatant have been analyzed by ELISA, STAT5a+b protein concentration in bone marrow mononuclear cells (BMMC) have been analyzed by Western blot, and mRNA expression of them have been detected in BMMC by RQ-PCR. The percentage of CD71+ cells in BMMC, apoptotic rate of CD71+ cells and ROS expression in CD71+ cells were detected by Flow cytometry.Results: Compared with the control group, the sEPO concentration, the efficacy of ESA and the expression of SOCS1, apoptotic rates of CD71+ cells and ROS expression in CD71+ cells in IO group were increased, the expression of STAT5 and BCL2L1 was reduced. Interestingly, after receiving ICT, some patients with EPO resistance have responded again to ESA treatment, with the decrease of the expression of SOCS1, apoptotic rates of CD71+ cells, ROS expression in CD71+ cells and the increase of the expression of STAT5 and BCL2L1.Conclusion: Iron overload can increase EPO resistance and the expression of SOCS1, inhibit the expression of STAT5 and BCL2L1. ICT could allivation of EPO resistance.
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“Iron chelation appears to directly inhibit the expression of FoxP3, the master switch transcription factor of Tregs.”
From Iron in infection and immunity (2020) · cites this paper as Zhang, 2020
In the citing paper
“In addition, levels of CD25 and phosphorylation of STAT5 are reduced upon iron chelation (Bonaccorsi-Riani et al., 2015; Zhang, 2020; Zhang et al. , 2018a,b,c).”
From Iron in infection and immunity (2020) · cites this paper as Zhang, 2020
Citations
Cites
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Cited by
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359
STAT5 as a Key Protein of Erythropoietin Signalization
Tóthová, Z., Tomc, J., Debeljak, N., & Solár, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137109 · Cited by 82
Iron metabolism in rheumatic diseases
Givian, A., Azizan, A., Jamshidi, A., Mahmoudi, M., & Farhadi, E. (2025) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2025.100267 · Cited by 10
Hemostatic therapy as a management strategy for acquired hemophilia: what does the future hold?
Franchini, M., Schiavulli, M., & Liumbruno, G. M. (2021) · Expert Review of Hematology · doi:10.1080/17474086.2021.1892483 · Cited by 7
Zhang, Y., Qian, Y., Song, L., Xiao, C. W., & Chang, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1058482 · Cited by 5
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Self-citationDetection and clinical application of red blood cell survival.
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Metadata
- Authors
- Zhang, Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Zhang, Yao
- ORCID
- Zhang, Yao
- Venue
- Hematology
- Publisher
- Informa UK Limited
- Published
- 2019-12-15
- Volume
- 25
- Issue
- 1
- Pages
- 1-10
- ISSN
- 1024-5332 (ISSN-L)
- 1607-8454
- OpenAlex
- W2994785145
- Cited by
- 9
- References
- 28
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Hematology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- iron chelation therapy, myelodysplastic syndrome, low-risk MDS, iron overload, erythropoietin resistance, SOCS1, STAT5, Bcl-xL, erythropoiesis-stimulating agents, apoptosis, reactive oxygen species, bone marrow mononuclear cells
- MeSH terms
- Adult, Aged, Aged, 80 and over, Erythropoietin, Female, Hematinics, Humans, Iron Chelating Agents, Male, Middle Aged, Myelodysplastic Syndromes, Signal Transduction, Chelation Therapy, Iron Overload, Tumor Suppressor Proteins, STAT5 Transcription Factor
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