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Cited by 198Polyamine Metabolism and ApplicationsGut microbiota and healthProbiotics and Fermented Foods

A wide diversity of bacteria from the human gut produces and degrades biogenic amines

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Pugin, Benoit, Barcik, Weronika, Westermann, Patrick, Heider, Anja, Wawrzyniak, Marcin, Hellings, Peter, Akdis, Cezmi A., O’Mahony, Liam·2017·Microbial Ecology in Health and Disease
DOI 10.1080/16512235.2017.1353881PMC PMC5614385
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Abstract

Background: Biogenic amines (BAs) are metabolites produced by the decarboxylation of amino acids with significant physiological functions in eukaryotic and prokaryotic cells. BAs can be produced by bacteria in fermented foods, but little is known concerning the potential for microbes within the human gut microbiota to produce or degrade BAs.Objective: To isolate and identify BA-producing and BA-degrading microbes from the human gastrointestinal tract.Design: Fecal samples from human volunteers were screened on multiple growth media, under multiple growth conditions. Bacterial species were identified using 16S rRNA sequencing and BA production or degradation was assessed using ultra-performance liquid chromatography.Results: In total, 74 BA-producing or BA-degrading strains were isolated from the human gut. These isolates belong to the genera Bifidobacterium, Clostridium, Enterococcus, Lactobacillus, Pediococcus, Streptococcus, Enterobacter, Escherichia, Klebsiella, Morganella and Proteus. While differences in production or degradation of specific BAs were observed at the strain level, our results suggest that these metabolic activities are widely spread across different taxa present within the human gut microbiota.Conclusions: The isolation and identification of microbes from the human gut with BA-producing and BA-degrading metabolic activity is an important first step in developing a better understanding of how these metabolites influence health and disease.

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  • Commensals Morganella morganii and E. coli have been shown to produce biogenic amines, including histamine.

    “For example, commensals Morganella morganii and E. coli, have been shown to produce biogenic amines (Pugin et al., 2017), including histamine (Behling and Taylor, 1982;Kim et al., 2000).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Pugin et al., 2017

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Authors
Pugin, B., Barcik, W., Westermann, P., Heider, A., Wawrzyniak, M., Hellings, P., Akdis, C. A., & O’Mahony, L.
Affiliations
  • University of Zurich (CH)
  • KU Leuven (BE)
  • Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich
Corresponding author
O’Mahony, Liam
ORCID
Venue
Microbial Ecology in Health and Disease
Publisher
Informa UK Limited
Published
2017-01
Volume
28
Issue
1
Pages
1353881-1353881
ISSN
  • 0891-060X (ISSN-L)
  • 1651-2235
DOI
10.1080/16512235.2017.1353881
PMC
PMC5614385
OpenAlex
W2739007479
Cited by
198
References
46
Citations by year
2026: 11 · 2025: 25 · 2024: 31 · 2023: 26 · 2022: 26 · 2021: 22 · 2020: 27 · 2019: 19 · 2018: 9 · 2017: 1
FWCI
6.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbial Ecology in Health and Disease (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
  • Lirias (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
SNSF (310030_144219, CRSII3_154488)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
biogenic amines, gut microbiota, amino acid decarboxylation, biogenic amine production, biogenic amine degradation, human gut bacteria, Bifidobacterium, Clostridium, Lactobacillus, Escherichia, Klebsiella, Proteus, Enterococcus

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