Factors associated with long turnaround time for early infant diagnosis of HIV in Myanmar
Open accessAbstract
Background: A previous review of early infant diagnosis (EID) using polymerase chain reaction technology (PCR) under integrated HIV care (IHC) program in Myanmar revealed a low uptake of timely (within 6 to 8 weeks of babies’ age) EID and a long turnaround time (TAT) of receiving results.Objective: This study aimed to determine the proportion and factors associated with the composite outcome of a long TAT (≥7 weeks; from sample collection to receipt of result by mother) or nonreceipt of result among HIV-exposed babies whose blood samples were collected for PCR at <9 months of age under the IHC program, Myanmar (2013–15).Methods: Cohort study involving record review of routinely collected data. A predictive Poisson regression model with robust variance estimates was fitted for risk factors of long TAT or nonreceipt of result.Results: Blood samples of 1 000 babies were collected; among them, long TAT or nonreceipt of results was seen in 690 (69%), and this was more than 50% across all subgroups. Babies with a mother’s CD4 count of 100–350 cells/mm3 at enrollment [adjusted RR (0.95 confidence intervals, CI): 0.8 (0.7, 0.9)] had a 20% lower risk of long TAT or nonreceipt of results when compared with ≥350 cells/mm3. Distance between ART center and PCR facility ≥105 km [adjusted RR (0.95 CI): 1.2 (1.1, 1.4)], when compared with <105 km, was associated with 20% higher risk of long TAT or nonreceipt of results.Conclusions: The proportion of babies with long TAT or nonreceipt of result by the mother was high. Point-of-care testing for EID may reduce TAT/nonreceipt of results by the mother. Health system, laboratory, and logistic factors such as sample transportation, laboratory procedures, and result dispatching associated with long TAT should be further explored.
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There are very few studies on machine learning to predict TAT or investigate factors affecting TAT in medical diagnostic laboratories.
“However, there are very few studies on ML to predict TAT or investigate factors affecting TAT in medical diagnostic laboratories [5,6].”
From Turnaround time prediction for clinical chemistry samples using machine learning (2022) · cites this paper as [5]
The Discussion (Key findings) says few studies had systematically analyzed factors associated with long turnaround time or nonreceipt of results for early infant HIV diagnosis. The Methods (Analysis and statistics) describe Poisson regression, not machine learning. The source supports the scarcity of studies investigating TAT factors in this specific setting, but not the claim about ML prediction or medical diagnostic laboratories generally. (LLM, conf=0.86)
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Turnaround time prediction for clinical chemistry samples using machine learning
Tsai, E. R., Demirtas, D., Hoogendijk, N., Tintu, A. N., & Boucherie, R. J. (2022) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2022-0668 · Cited by 17 · see citing works
- Authors
- Thiha, S., Shewade, H. D., Philip, S., Aung, T. K., Kyaw, N. T. T., Oo, M. M., Kyaw, K. W. Y., Wint War, M., & Oo, H. N.
- Affiliations
- International Union Against Tuberculosis and Lung Disease (FR)
- International Union Against Tuberculosis and Lung Disease (US)
- T. D. Medical College (IN)
- Public Health Laboratory, Department of Medical Services, Ministry of Health and Sports, Mandalay, Myanmar
- Ministry of Health and Sports (MM)
- Corresponding author
- Thiha, Soe
- ORCID
- Venue
- Global Health Action
- Publisher
- Informa UK Limited
- Published
- 2017-01
- Volume
- 10
- Issue
- 1
- Pages
- 1395657-1395657
- ISSN
- 1654-9716 (ISSN-L)
- 1654-9880
- PMC
- PMC5700493
- OpenAlex
- W2767559949
- Cited by
- 18
- References
- 0
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 2
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Global Health Action (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Global Maternal and Child Health
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- early infant HIV diagnosis, turnaround time, HIV-exposed infants, mother-to-child HIV transmission, maternal CD4 count, point-of-care testing, Myanmar
- MeSH terms
- Myanmar, Female, Humans, Infant, Infant, Newborn, Male, Risk Factors, Time Factors, Cohort Studies, HIV Infections, Infectious Disease Transmission, Vertical, Early Diagnosis
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