Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond
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Introduction: This Experts’ opinion provides an updated scientific support to gynecologists, obstetricians, endocrinologists, nutritionists, neurologists and general practitioners on the use of Inositols in the therapy of Polycystic Ovary Syndrome (PCOS) and non-insulin dependent (type 2) diabetes mellitus (NIDDM).Areas covered: This paper summarizes the physiology of Myo-Inositol (MI) and D-Chiro-Inositol (DCI), two important molecules present in human organisms, and their therapeutic role, also for treating infertility. Some deep differences between the physiological functions of MI and DCI, as well as their safety and intestinal absorption are discussed. Updates include new evidence on the efficacy exerted in PCOS by the 40:1 MI/DCI ratio, and the innovative approach based on alpha-lactalbumin to overcome the decreased therapeutic efficacy of Inositols in some patients.Expert opinion: The evidence suggests that MI, alone or with DCI in the 40:1 ratio, offers a promising treatment for PCOS and NIDDM. However, additional studies need to evaluate some still unresolved issues, such as the best MI/DCI ratio for treating NIDDM, the potential cost-effectiveness of reduced gonadotropins administration in IVF due to MI treatment, or the benefit of MI supplementation in ovulation induction with clomiphene citrate in PCOS patients.
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References 169 · Cited by 63
- Authors
- Facchinetti, F., Appetecchia, M., Aragona, C., Bevilacqua, A., Bezerra Espinola, M. S., Bizzarri, M., D’Anna, R., Dewailly, D., Diamanti-Kandarakis, E., Hernández Marín, I., Kamenov, Z. A., Kandaraki, E., Laganà, A. S., Monastra, G., Montanino Oliva, M., Nestler, J. E., Orio, F., Ozay, A. C., Papalou, O., Pkhaladze, L., Porcaro, G., Prapas, N., Soulage, C. O., Stringaro, A., Wdowiak, A., & Unfer, V.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Instituto Nazionale Tumori Regina Elena (IT)
- Sapienza University of Rome (IT)
- Systems Biology Group Lab, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
- University of Messina (IT)
- Inserm (FR)
- Department of Endocrinology & Diabetes, HYGEIA Hospital, Marousi, Athens, Greece
- Human Reproduction Department, Hospital Juárez de México, México City Mexico
- Medical University of Sofia (BG)
- Hygeia Hospital (GR)
- University of Insubria (IT)
- Department of Obstetrics and Gynecology, “Santo Spirito” Hospital, Rome, Italy
- Virginia Commonwealth University (US)
- Parthenope University of Naples (IT)
- Faculty of Medicine, Department of Obstetrics and Gynecology, Near East University, Nicosia Cyprus
- Department of Gynecological Endocrinology, Ioseb Zhordania Institute of Reproductology, Tbilisi, Georgia
- Women’s Health Center, Orvieto, Italy
- Aristotle University of Thessaloniki (GR)
- Lyon 1 Université (FR)
- Istituto Superiore di Sanità (IT)
- Medical University of Lublin (PL)
- Corresponding author
- Unfer, Vittorio
- ORCID
- Venue
- Expert Opinion on Drug Metabolism & Toxicology
- Publisher
- Informa UK Limited
- Published
- 2020-03-03
- Volume
- 16
- Issue
- 3
- Pages
- 255-274
- ISSN
- 1742-5255 (ISSN-L)
- 1744-7607
- OpenAlex
- W3009517767
- Cited by
- 63
- References
- 169
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 12 · 2022: 4 · 2021: 15 · 2020: 18
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by
- Locations
- Expert Opinion on Drug Metabolism & Toxicology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- myo-inositol, D-chiro-inositol, polycystic ovary syndrome, type 2 diabetes, infertility, alpha-lactalbumin, intestinal absorption, safety, ovulation induction, clomiphene citrate, in vitro fertilization, human reproduction
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Expert Testimony, Female, Humans, Inositol, Polycystic Ovary Syndrome, Reproduction, Vitamin B Complex
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