The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A biocompatible medium for nanoparticle dispersion
Abstract
Our laboratory has reported that rat bronchoalveolar lavage (BAL) fluid is an effective nanoparticle (NP) dispersant. However, its utility is constrained by its cost and the lack of standardization to control for intra- and inter-laboratory variability in BAL fluid. In this study, we report the efficacy and biocompatibility of a dispersion medium (DM), which is a ‘lung fluid mimic’. In vitro studies, which used dynamic light scattering and transmission electron microscopy, determined that ultrafine titanium dioxide and ultrafine carbon black are equally well dispersed by DM or BAL fluid. We also determined that DM was effective at dispersing multi-walled carbon nanotubes. In vivo, when used as a vehicle, DM per se did not elicit toxicity and did not influence or alter toxic responses to crystalline silica in either the lung or brain. Overall, these studies indicate that DM is an effective, biocompatible, and economical vehicle for nanotoxicological studies.
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Citations
Cites
Porter, D. W., Barger, M., Robinson, V. A., Leonard, S. S., Landsittel, D., & Castranova, V. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00061-6 · Cited by 46
Self-citation
Cited by
Stability and Aggregation of Metal Oxide Nanoparticles in Natural Aqueous Matrices
Keller, A. A., Wang, H., Zhou, D., Lenihan, H. S., Cherr, G., Cardinale, B. J., Miller, R., & Ji, Z. (2010) · Environmental Science & Technology · doi:10.1021/es902987d · Cited by 1,369
Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes
Porter, D. W., Hubbs, A. F., Mercer, R. R., Wu, N., Wolfarth, M. G., Sriram, K., Leonard, S., Battelli, L., Schwegler-Berry, D., Friend, S., et al. (2010) · Toxicology · doi:10.1016/j.tox.2009.10.017 · Cited by 538
Self-citationToxicity assessment of nanomaterials: methods and challenges
Dhawan, A., & Sharma, V. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3996-x · Cited by 466
Xia, T., Zhao, Y., Sager, T., George, S., Pokhrel, S., Li, N., Schoenfeld, D., Meng, H., Lin, S., Wang, X., et al. (2011) · ACS Nano · doi:10.1021/nn1028482 · Cited by 379
Self-citationRittinghausen, S., Hackbarth, A., Creutzenberg, O., Ernst, H., Heinrich, U., Leonhardt, A., & Schaudien, D. (2014) · Particle and Fibre Toxicology · doi:10.1186/s12989-014-0059-z · Cited by 193
Metadata
- Authors
- Porter, D., Sriram, K., Wolfarth, M., Jefferson, A., Schwegler-Berry, D., Andrew, M. E., & Castranova, V.
- Venue
- Nanotoxicology
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 2
- Issue
- 3
- Pages
- 144-154
- ISSN
- 1743-5390 (ISSN-L)
- 1743-5404
- OpenAlex
- W2032831754
- Cited by
- 196
- References
- 1
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Porter, D., Sriram, K., Wolfarth, M., Jefferson, A., Schwegler-Berry, D., Andrew, M. E., & Castranova, V. (2008). A biocompatible medium for nanoparticle dispersion. Nanotoxicology. https://doi.org/10.1080/17435390802318349
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