The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Mitochondria and Iron: current questions
Open accessAbstract
INTRODUCTION: Mitochondria are cellular organelles that perform numerous bioenergetic, biosynthetic, and regulatory functions and play a central role in iron metabolism. Extracellular iron is taken up by cells and transported to the mitochondria, where it is utilized for synthesis of cofactors essential to the function of enzymes involved in oxidation-reduction reactions, DNA synthesis and repair, and a variety of other cellular processes. Areas covered: This article reviews the trafficking of iron to the mitochondria and normal mitochondrial iron metabolism, including heme synthesis and iron-sulfur cluster biogenesis. Much of our understanding of mitochondrial iron metabolism has been revealed by pathologies that disrupt normal iron metabolism. These conditions affect not only iron metabolism but mitochondrial function and systemic health. Therefore, this article also discusses these pathologies, including conditions of systemic and mitochondrial iron dysregulation as well as cancer. Literature covering these areas was identified via PubMed searches using keywords: Iron, mitochondria, Heme Synthesis, Iron-sulfur Cluster, and Cancer. References cited by publications retrieved using this search strategy were also consulted. Expert commentary: While much has been learned about mitochondrial and its iron, key questions remain. Developing a better understanding of mitochondrial iron and its regulation will be paramount in developing therapies for syndromes that affect mitochondrial iron.
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Cited by
The role of zinc, copper, manganese and iron in neurodegenerative diseases
Mezzaroba, L., Alfieri, D. F., Colado Simão, A. N., & Vissoci Reiche, E. M. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.07.007 · Cited by 524
Iron Metabolism in Obesity and Metabolic Syndrome
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Why cells need iron: a compendium of iron utilisation
Teh, M. R., Armitage, A. E., & Drakesmith, H. (2024) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2024.04.015 · Cited by 114
Smoking-induced iron dysregulation in the lung
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Metadata
- Authors
- Paul, B. T., Manz, D. H., Torti, F. M., & Torti, S. V.
- Venue
- Expert Review of Hematology
- Publisher
- Informa UK Limited
- Published
- 2016-12-12
- Volume
- 10
- Issue
- 1
- Pages
- 65-79
- ISSN
- 1747-4086 (ISSN-L)
- 1747-4094
- OpenAlex
- W2559410759
- Cited by
- 423
- References
- 23
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- green
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