Design, power, and interpretation of studies in the standard murine model of ALS

Scott, Sean, Kranz, Janice E., Cole, Jeff, Lincecum, John M., Thompson, Kenneth, Kelly, Nancy, Bostrom, Alan, Theodoss, Jill +4 more·2008·Amyotrophic Lateral Sclerosis

Cited by (503)

Items 301–400 of 503

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  11. Potential new complication in drug therapy development for amyotrophic lateral sclerosis
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  12. From mice to mind: Strategies and progress in translating neuroregeneration
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  13. The motor neuron m6A repertoire governs neuronal homeostasis and FTO inhibition mitigates ALS symptom manifestation
    Ya-Ping Yen, Ting-Hsiang Lung, Ee Shan Liau, Chuan‐Che Wu, Guanlin Huang, Fang-Yu Hsu, Mien Chang, Zheng-Dao Yang, Chia-Yi Huang, Zhong Zheng et al. · 2025 · Nature Communications
  14. Preclinical trials in Alzheimer’s disease: Sample size and effect size for behavioural and neuropathological outcomes in 5xFAD mice
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  18. Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration
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  19. Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons
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  20. Replication – why we need to publish our findings
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  21. Activity-dependent degeneration of axotomized neuromuscular synapses in WldS mice
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  22. Focal and dose-dependent neuroprotection in ALS mice following AAV2-neurturin delivery
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  23. Pathway identification through transcriptome analysis
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  24. Effects of RAGE inhibition on the progression of the disease in hSOD1<sup>G93A</sup> ALS mice
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  25. AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model mice
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  27. NU-9 improves health of hSOD1G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone
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  34. Statistical Rigor and the Perils of Chance
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  36. α CAR IGF ‐1 vector targeting of motor neurons ameliorates disease progression in ALS mice
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  37. Synergistic Effects of Riluzole and Sodium Butyrate on Barrier Function and Disease Progression of Amyotrophic Lateral Sclerosis Through the Gut‐Neuron Axis
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  38. Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression
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  39. Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord
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  40. Animal and cellular models of human disease
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  41. Ethics of Animal Research
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  42. IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
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  43. Optimizing Mouse Models of Neurodegenerative Disorders: Are Therapeutics In Sight?
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  44. Non-Methylation-Linked Mechanism of REST-Induced Neuroglobin Expression Impacts Mitochondrial Phenotypes in a Mouse Model of Amyotrophic Lateral Sclerosis
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  45. New forms of checks and balances are needed to improve research integrity
    Elizabeth J. Iorns, Christin Chong · 2014 · F1000Research
  46. Presymptomatically applied AMPA receptor antagonist prevents calcium increase in vulnerable type of motor axon terminals of mice modeling amyotrophic lateral sclerosis
    Roland Patai, Melinda Paizs, Massimo Tortarolo, Caterina Bendotti, Izabella Obál, József I. Engelhardt, László Siklós · 2017 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  47. New animal models of progressive neurodegeneration: tools for identifying targets in predictive diagnostics and presymptomatic treatment
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  49. Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain
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  50. Ok Google, how could I design therapeutics against prion diseases?
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  53. 5-Hydroxytryptamine: a potential therapeutic target in amyotrophic lateral sclerosis
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  54. Contribution of the Breadth and Depth of IACUC Membership to Experimental Design as a Factor in Research Reproducibility.
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  56. Logical Experimental Design and Execution in the Biomedical Sciences
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