Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson’s disease
Open accessAbstract
Parkinson's disease (PD) is a common neurodegenerative disorder characterized primarily by motor and non-motor gastrointestinal (GI) deficits. GI symptoms' including compromised intestinal barrier function often accompanies altered gut microbiota composition and motor deficits in PD. Therefore, in this study, we set to investigate the role of gut microbiota and epithelial barrier dysfunction on motor symptom generation using a rotenone-induced mouse model of PD. We found that while six weeks of 10 mg/kg of chronic rotenone administration by oral gavage resulted in loss of tyrosine hydroxylase (TH) neurons in both germ-free (GF) and conventionally raised (CR) mice, the decrease in motor strength and coordination was observed only in CR mice. Chronic rotenone treatment did not disrupt intestinal permeability in GF mice but resulted in a significant change in gut microbiota composition and an increase in intestinal permeability in CR mice. These results highlight the potential role of gut microbiota in regulating barrier dysfunction and motor deficits in PD.
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The development of GI dysfunction and motor symptoms following chronic rotenone administration occurs only in conventionally raised mice, but not in GF mice.
“In addition, the development of GI dysfunction and motor symptoms following chronic rotenone administration occurs only in conventionally raised mice, but not in GF mice.218”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [218]
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References 34 · Cited by 126
- Authors
- Bhattarai, Y., Si, J., Pu, M., Ross, O. A., McLean, P. J., Till, L., Moor, W., Grover, M., Kandimalla, K. K., Margolis, K. G., Farrugia, G., & Kashyap, P. C.
- Affiliations
- Mayo Clinic (US)
- University of Minnesota (US)
- Morgan Stanley Children's Hospital (US)
- Corresponding author
- Bhattarai, Yogesh
- Kashyap, Purna C.
- ORCID
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2021-01-01
- Volume
- 13
- Issue
- 1
- Pages
- 1866974-1866974
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC7833732
- OpenAlex
- W3121396168
- Cited by
- 126
- References
- 34
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 28 · 2023: 20 · 2022: 23 · 2021: 14
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Gut Microbes (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (DK114007)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Parkinson's disease, gut microbiota, gastrointestinal dysfunction, motor symptoms, intestinal barrier dysfunction, intestinal permeability, rotenone, germ-free mice, tyrosine hydroxylase neurons, neurodegeneration
- MeSH terms
- Gastrointestinal Microbiome, Brain-Gut Axis, Animals, Disease Models, Animal, Female, Gastrointestinal Diseases, Germ-Free Life, Male, Parkinson Disease, Rotenone, Tyrosine 3-Monooxygenase, Tight Junctions, Dystonic Disorders, Gastrointestinal Tract, Mice, Dysbiosis
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