Chromatin structure and gene regulation: a dynamic view of enhancer function
Open accessAbstract
Localized chromatin organization is now recognized as an important determinant of cell identity and developmental pathways. Recent studies have demonstrated that these epigenetic states are unexpectedly dynamic and malleable. In this Extra view we will highlight the transient nature of stimulus-induced enhancer accessibility and its importance for transcription regulation. Using glucocorticoid receptor (GR) as a model system we will discuss spatiotemporal relationships between receptor/chromatin interactions, lifetimes of the DNase I hypersensitivity sites (DHSs), long-range interactions, and gene regulation. We propose that differential temporal activation and utilization of distal regulatory elements plays a role in directing divergent stimulus-induced transcriptional programs.
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TFs do not bind DNA for periods of time longer than a few seconds.
“In contrast to the long-held view, an accumulating body of work suggests that TFs do not bind DNA for periods of time longer than a few seconds26, 27.”
From Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading (2017) · cites this paper as [27]
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References 60 · Cited by 24
- Authors
- Stavreva, D. A., & Hager, G. L.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Stavreva, Diana A
- Hager, Gordon L
- Venue
- Nucleus
- Publisher
- Informa UK Limited
- Published
- 2015-11-02
- Volume
- 6
- Issue
- 6
- Pages
- 442-448
- ISSN
- 1949-1034 (ISSN-L)
- 1949-1042
- PMC
- PMC4915511
- OpenAlex
- W2300194142
- Cited by
- 24
- References
- 60
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nucleus (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- enhancer accessibility, chromatin organization, glucocorticoid receptor, DNase I hypersensitive sites, long-range chromatin interactions, transcriptional regulation, epigenetic dynamics, distal regulatory elements, cell identity
- MeSH terms
- Animals, Binding Sites, Chromatin, Deoxyribonuclease I, Enhancer Elements, Genetic, Gene Expression Regulation, Humans, Models, Molecular, Receptors, Glucocorticoid, RNA, Transcription Factors, CRISPR-Cas Systems
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