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Cited by 45Chromatin Remodeling and CancerGenomics and Chromatin DynamicsNuclear Structure and Function

Mechanism of Action of the SWI/SNF Family Complexes

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Chen, Kangjing, Yuan, Junjie, Sia, Youyang, Chen, Zhucheng·2023·Nucleus
DOI 10.1080/19491034.2023.2165604PMC PMC9839376
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Abstract

DNA wraps around histone octamers to assemble nucleosomes, which pack into high-ordered chromatin structure in the nucleus, and block access to the genetic material.The SWI/SNF family chromatin remodeling complexes are multi-subunit, ATP-dependent molecular machines that slide and evict nucleosomes.They play a major role in control of the chromatin structure and regulate gene transcription in eukaryotic cells.Mutations of the human complexes are often found in cancers and neurodevelopmental disorders.Here, we review recent studies of the structures of the yeast complexes (SWI/SNF and RSC) and the human homologs (BAF and PBAF).We discuss how the subunits interweave into functional modules and submodules.We discuss the conserved mode of nucleosome recognition across evolution, and propose the mechanism of chromatin targeting through interaction with transcription factors and histone modifications.We also discuss the implications of disease-associated mutations in the regulation of chromatin remodeling.These findings shed light on the mechanism and function of the SWI/SNF family complexes, and provide the structural basis for drug development.

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  • SWI/SNF complex interacts directly with key tumor suppressors and oncogenes such as RB, BRCA1, c-MYC, and MLL, impacting genes crucial for cell proliferation, differentiation, and survival.

    “The SWI/SNF complex interacts directly with key tumor suppressors and oncogenes such as RB, BRCA1, c-MYC, and MLL, impacting genes crucial for cell proliferation, differentiation, and survival [72].”

    From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [72]

    The Future perspective (page unavailable) says defective mSWI/SNF complexes deregulate gene transcription, and the disease-associated mutations section links these complexes to cancer. But the passages do not establish direct interactions with RB, BRCA1, c-MYC, or MLL, or the claimed effects on genes governing proliferation, differentiation, and survival; searches for those names and terms found no supporting passage. (LLM, conf=0.82)

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  • SWI/SNF complex dysregulation is linked to cancer.

    “The SWI/SNF complex is indeed a crucial player in chromatin remodeling, and its dysregulation is linked to cancer.”

    From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [72]

  • In mammalian cells, the ortholog of MCM1, SRF, activates immediate early genes.

    “In mammalian cells, the ortholog of MCM1, Serum Response Factor (SRF), activates immediate early genes [72,74].”

    From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [72]

    The Introduction discusses conservation of SWI/SNF complexes between yeast and mammals, and the Linker DNA recognition section discusses transcription factors, but neither addresses SRF as an MCM1 ortholog or its activation of immediate early genes. Searches for “Serum Response Factor SRF activates immediate early genes” and “MCM1 ortholog mammalian immediate early genes” found no passage supporting the claim. Page numbers were not available in our copy. (LLM, conf=0.73)

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Authors
Chen, K., Yuan, J., Sia, Y., & Chen, Z.
Affiliations
  • Tsinghua University (CN)
  • Center for Life Sciences (CN)
Corresponding author
Chen, Zhucheng
ORCID
Venue
Nucleus
Publisher
Informa UK Limited
Published
2023-01-12
Volume
14
Issue
1
Pages
2165604-2165604
ISSN
  • 1949-1034 (ISSN-L)
  • 1949-1042
DOI
10.1080/19491034.2023.2165604
PMC
PMC9839376
OpenAlex
W4315754657
Cited by
45
References
3
Citations by year
2026: 17 · 2025: 11 · 2024: 9 · 2023: 8
FWCI
4.01
Type
journal article
Language
en
Open access
Licence
Locations
  • Nucleus (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (32130016)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
SWI/SNF complex, chromatin remodeling, nucleosome eviction, nucleosome recognition, chromatin structure, transcriptional regulation, PBAF, RSC complex, histone modifications, transcription factors, chromatin targeting, disease-associated mutations, cancer, neurodevelopmental disorders, drug development
MeSH terms
DNA-Binding Proteins, Nucleosomes, Chromatin Assembly and Disassembly

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