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Cited by 277Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

The regulation of hyphae growth in Candida albicans

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Chen, Hui, Zhou, Xuedong, Ren, Biao, Cheng, Lei·2020·Virulence
DOI 10.1080/21505594.2020.1748930PMC PMC7161696
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Abstract

In the last decades, Candida albicans has served as the leading causal agent of life-threatening invasive infections with mortality rates approaching 40% despite treatment. Candida albicans (C. albicans) exists in three biological phases: yeast, pseudohyphae, and hyphae. Hyphae, which represent an important phase in the disease process, can cause tissue damage by invading mucosal epithelial cells then leading to blood infection. In this review, we summarized recent results from different fields of fungal cell biology that are instrumental in understanding hyphal growth. This includes research on the differences among C. albicans phases; the regulatory mechanism of hyphal growth, extension, and maintaining cutting-edge polarity; cross regulations of hyphal development and the virulence factors that cause serious infection. With a better understanding of the mechanism on mycelium formation, this review provides a theoretical basis for the identification of targets in candidiasis treatment. It also gives some reference to the study of antifungal drugs.

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  • The cAMP-PKA signaling pathway regulates hyphal development under conditions of altered metabolism in C. albicans.

    “the cAMP–PKA signaling pathway, which is known to regulate hyphal development under conditions of altered metabolism in C. albicans (Chen et al. 2020a; Lassak et al. 2011).”

    From Aloe emodin disrupts Candida albicans mitochondrial iron homeostasis against its hyphal development and oral candidiasis (2026) · cites this paper as Chen et al. 2020a

    The cAMP-PKA subsection under “Signaling pathways of hyphal morphogenesis” says the pathway has a key role in C. albicans morphogenesis and energy metabolism, and describes PKA components involved in hyphal growth under different induction conditions. It does not specifically establish that the pathway regulates hyphal development under conditions of altered metabolism. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • The cAMP-PKA signaling pathway is a central regulator of hyphal development in C. albicans.

    “a central regulator of hyphal development”

    From Aloe emodin disrupts Candida albicans mitochondrial iron homeostasis against its hyphal development and oral candidiasis (2026) · cites this paper as Chen et al. 2020a

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References 123 · Cited by 277

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Authors
Chen, H., Zhou, X., Ren, B., & Cheng, L.
Affiliations
Sichuan University (CN)
Corresponding author
  • Ren, Biao
  • Cheng, Lei
ORCID
Venue
Virulence
Publisher
Informa UK Limited
Published
2020-04-10
Volume
11
Issue
1
Pages
337-348
ISSN
  • 2150-5594 (ISSN-L)
  • 2150-5608
DOI
10.1080/21505594.2020.1748930
PMC
PMC7161696
OpenAlex
W3016029167
Cited by
277
References
123
Citations by year
2026: 36 · 2025: 56 · 2024: 65 · 2023: 52 · 2022: 42 · 2021: 23 · 2020: 3
FWCI
2.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Virulence (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81430011)
  • National Natural Science Foundation of China grant (81870759, 81600858, 81870778)
  • Innovative Research Team Program of Sichuan Province (none)
  • Grant of the Science and Technology Department of Sichuan Province, China (2017JQ0028)
  • State Key Laboratory of Oral Disease (SKLOD201913)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Candida albicans, hyphal growth, hyphal polarity, mycelium formation, fungal virulence factors, invasive candidiasis, antifungal drug targets, fungal cell biology
MeSH terms
Candida albicans, Candidiasis, Fungal Proteins, Humans, Virulence, Gene Expression Regulation, Fungal, Hyphae

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