Aging, cytomegalovirus (CMV) and influenza vaccine responses
Open accessAbstract
Influenza vaccination is less effective in elderly as compared to young individuals. Several studies have identified immune biomarkers able to predict a protective humoral immune response to the vaccine. In this review, we summarize current knowledge on the effects of aging on influenza vaccine responses and on biomarkers so far identified, and we discuss the relevance of latent cytomegalovirus (CMV) infection on these vaccine responses.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In influenza vaccination, decreased T-cell function and loss of CD28 expression are among the characterized defects.
“For example, in the case of influenza vaccination, the following defects have been characterized: decreased T-cell function and loss of CD28 expression, reduced specificity and class of antibody produced and decreased memory B cells, reduced natural killer cell cytotoxicity on a per cell basis, and reduced number and/or function of circulating dendritic cells (reviewed in [120]).”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [120]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 117 · Cited by 46
Research works printed but not linked: 3
- Loerbroks ASC, Bosch JA, Litaker DG, Apfelbacher CJ. Influ- enza vaccination coverage among high-risk groups in 11 Euro- pean countries. Eur J Public Health 2011; 22(4):562-8; PMID:21750011
- Frasca D, Diaz A, Romero M, Mendez NV, Landin AM, Ryan JG, Blomberg BB. Young and elderly patients with type 2 diabetes have optimal B cell responses to the seasonal influenza vaccine. Vaccine 2013; 31(35):3603-10; PMID:23711934
- Sayegh CE, Quong MW, Agata Y, Murre C. E-proteins directly reg- ulate expression of activation-induced deaminase in mature B cells. Nat Immunol 2003; 4:586-93; PMID:12717431; http://dx.doi.org/ 10.1038/ni923 · DOI
- Authors
- Frasca, D., & Blomberg, B. B.
- Affiliations
- University of Miami (US)
- Corresponding author
- Frasca, Daniela
- Venue
- Human Vaccines & Immunotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2015-11-20
- Volume
- 12
- Issue
- 3
- Pages
- 682-690
- ISSN
- 2164-5515 (ISSN-L)
- 2164-554X
- PMC
- PMC4964725
- OpenAlex
- W2174825619
- Cited by
- 46
- References
- 117
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 6
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Vaccines & Immunotherapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AG-32576, AG042826)
- National Institute on Aging (R01AG032576, R37AG023717, R56AG032576)
- National Institute of Allergy and Infectious Diseases (R21AI096446)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- influenza vaccination, aging, cytomegalovirus, vaccine response, immunological markers, humoral immune response, older adults, immunosenescence
- MeSH terms
- Aging, Antibodies, Viral, Cytomegalovirus Infections, Cytomegalovirus, Humans, Influenza Vaccines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
