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Epigallocatechin-3-gallate suppresses the growth of human osteosarcoma by inhibiting the Wnt/β-catenin signalling pathway
Open accessAbstract
Osteosarcoma (OS) is one of the most common malignant tumors in adolescents. Due to local invasion, distant metastasis and drug resistance, the clinical treatment efficacy and prognosis of OS have remained almost unchanged for decades. Epigallocatechin-3-gallate (EGCG) is a unique catechin from tea leaves, and some studies have confirmed its antitumour effects on various tumors. Here, cellular experiments showed that EGCG significantly promoted OS cell apoptosis and inhibited proliferation, migration and invasion, and cell and animal experiments demonstrated that the Wnt/β-catenin pathway played an indispensable role in the antitumour effects of EGCG. Moreover, EGCG inhibited the growth of OS cells in vitro while suppressing tumor cell damage to the bone in situ and distant lung metastasis. The results indicate that the antitumour effect of EGCG on human OS may be mediated by regulating the Wnt/β-catenin pathway and that EGCG can be used alone or in combination with other regimens as a potentially effective anticancer treatment.
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Overexpression of β-catenin can either augment or reduce the anticancer effects of EGCG.
“Dong and colleagues reported the nuanced relationship between EGCG and the WNT/β-catenin signaling pathway by demonstrating that overexpression of β-catenin could either augment or reduce the anticancer effects of EGCG.147”
From Drug repurposing for cancer therapy (2024) · cites this paper as [147]
In “EGCG inhibits OS growth by regulating the Wnt/β-catenin pathway” (Figure 4c–f; page not supplied), the paper reports that β-catenin overexpression inhibited EGCG’s antitumour and pro-apoptotic effects. It was β-catenin knockdown, not overexpression, that strengthened those effects. (LLM, conf=0.91)
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References 32 · Cited by 25
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Metadata
- Authors
- Dong, C., Wang, Z., Shen, P., Chen, Y., Wang, J., & Wang, H.
- Affiliations
- Department of General Surgery, Chongqing Traditional Chinese Medicine Hospital, Chongqing, P.R. China
- Department of Dermatology and Cosmetology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, P.R. China
- Corresponding author
- Wang, Jinshu
- Wang, Hongbo
- Venue
- Bioengineered
- Publisher
- Informa UK Limited
- Published
- 2022-03-29
- Volume
- 13
- Issue
- 4
- Pages
- 8490-8502
- ISSN
- 2165-5979 (ISSN-L)
- 2165-5987
- PMC
- PMC9161922
- OpenAlex
- W4221057472
- Cited by
- 25
- References
- 32
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 1 · 2023: 5 · 2022: 2
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Bioengineered (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- the performance incentive and guidance project of Chongqing Scientific Research Institutions (jxyn2020-8)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- epigallocatechin gallate, osteosarcoma, Wnt/β-catenin signaling, catechins, tea, apoptosis, cell proliferation, cell migration and invasion, lung metastasis, anticancer activity, anticancer treatment
- MeSH terms
- Animals, Bone Neoplasms, Catechin, Humans, Osteosarcoma, Apoptosis, Cell Line, Tumor, Cell Proliferation, beta Catenin, Wnt Signaling Pathway
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