Application of arteether-loaded polyurethane nanomicelles to induce immune response in breast cancer model
Open accessAbstract
To concentrate a potent anticancer drug (Arteether) in tumor microenvironment, we encapsulated it in biodegradable and pH sensitive polyurethane (PU) nanomicelles (NMs). The nanocomplex was characterized by Fourier transform infrared (FTIR), dynamic light scattering (DLS). The loading capacity and release profile in pH of 5.4 and 7.4 were considered. The cytotoxicity effect was evaluated in vitro and in vivo settings. The level of IFN-γ and IL-4 cytokines of mice splenocytes were assessed by enzyme-linked immunosorbent assay (ELISA). The nanocomplex showed negative zeta charge of -26.2 mV, size of 42.30 nm and high loading capacity (92%). Release profile showed a faster rate of drug liberation at pH 5.4 as compared to that of pH 7.4. It indicated significant inhibitory effect on the growth of 4T1 cell line and increased IFN-γ level.
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Conventional 2D cell monolayers and 3D cell culture models are unable to recapitulate the complex biochemical and biophysical factors of the tumor microenvironment in vivo because they lack the systemic nature of tumors, leading to weak predictive ability.
“2D cell monolayers and three-dimensional cell culture models have been widely employed as initial screening models to provide a cost-efficient and simplified method to elucidate the mechanism of cancer biology or identify the efficacy and safety of a drug candidate14–16; however, they are unable to recapitulate complex biochemical and biophysical factors of the tumor microenvironment (TME) in vivo”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [22]
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References 39 · Cited by 24
- Authors
- Jabbarzadegan, M., Rajayi, H., Mofazzal Jahromi, M. A., Yeganeh, H., Yousefi, M., Muhammad Hassan, Z., & Majidi, J.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Tarbiat Modares University (IR)
- Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University
- Iran Polymer and Petrochemical Institute (IR)
- Corresponding author
- Majidi, Jafar
- Venue
- Artificial Cells, Nanomedicine, and Biotechnology
- Publisher
- Informa UK Limited
- Published
- 2016-06-05
- Volume
- 45
- Issue
- 4
- Pages
- 808-816
- ISSN
- 2169-1401 (ISSN-L)
- 2169-141X
- OpenAlex
- W2410951696
- Cited by
- 24
- References
- 39
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 3
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Artificial Cells Nanomedicine and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tabriz University of Medical Sciences (126-92)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- arteether, breast cancer, pH-responsive drug delivery, tumor microenvironment, drug encapsulation, controlled drug release, 4T1 cells, interferon-gamma, IL-4, immune response, anticancer drug delivery
- MeSH terms
- Animals, Antineoplastic Agents, Breast Neoplasms, Drug Carriers, Female, Hydrogen-Ion Concentration, Mammary Neoplasms, Experimental, Mice, Inbred BALB C, Micelles, Polyurethanes, Solubility, Water, Cytokines, Artemisinins, Cell Line, Tumor, Tumor Burden, Mice, Nanoparticles, Hydrophobic and Hydrophilic Interactions, Drug Liberation
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