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Cited by 19Intestinal and Peritoneal AdhesionsElectrospun Nanofibers in Biomedical ApplicationsSilk-based biomaterials and applications

Prevention of peritoneal adhesions formation by core-shell electrospun ibuprofen-loaded PEG/silk fibrous membrane

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Nadri, Samad, Rahmani, Ali, Hosseini, Seyed Hojjat, Habibizadeh, Mina, Araghi, Mahmood, Mostafavi, Hossein·2022·Artificial Cells, Nanomedicine, and Biotechnology
DOI 10.1080/21691401.2021.1883043
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Abstract

Adhesion bands are pathological fibrous tissues that create in the middle of tissues and organs, often reasons of intestinal obstruction, and female infertility. Here, we explored the anti-adhesive and inflammatory capacities of PEG/silk and Ibuprofen-loaded PEG/Silk core-shell nanofibrous membranes, respectively. The ibuprofen-loaded Silk Fibroin-Poly ethylene Glycol (SF-PEG) core-shell membrane was fabricated by electrospinning and considered in terms of morphology, surface wettability, drug release, and degradation. To reveal the membrane capability for adhesion bands inhibition, the membrane was stitched among the abdominal partition and peritoneum and then evaluated using two scoring adhesion systems. According to results, the fibrous membrane hindered cell proliferation, and the scoring systems and pathology showed that in a rat model, Ibuprofen-loaded PEG/Silk core-shell membrane caused a lightening in post-operative adhesion bands and the low-grade inflammatory reaction in animal models. Collectively, we fabricated new ibuprofen-loaded PEG/SF membranes with anti-adhesion and anti-inflammation properties. Moreover, this core-shell electrospun fibrous membrane has not even now been used to prevent peritendinous adhesion generation.

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  • Electrospun anti-adhesion films can be made from biodegradable polymers and can incorporate drugs by techniques like coaxial (core-shell) electrospinning.

    “Electrospun anti-adhesion films can be made from biodegradable polymers and even incorporate drugs by techniques like coaxial (core–shell) electrospinning [12,271].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [271]

  • An ibuprofen-loaded PEG/silk fibroin core-shell nanofiber membrane placed between injured peritoneal surfaces lightened adhesion bands and caused only a low-grade inflammatory reaction in rats.

    “Similarly, an ibuprofen-loaded PEG/silk fibroin core–shell nanofiber membrane, placed between injured peritoneal surfaces, lightened adhesion bands and caused only a low-grade inflammatory reaction in rats [271].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [271]

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Authors
Nadri, S., Rahmani, A., Hosseini, S. H., Habibizadeh, M., Araghi, M., & Mostafavi, H.
Affiliations
  • Zanjan University of Medical Sciences (IR)
  • Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Corresponding author
Nadri, Samad
ORCID
Venue
Artificial Cells, Nanomedicine, and Biotechnology
Publisher
Informa UK Limited
Published
2022-03-17
Volume
50
Issue
1
Pages
40-48
ISSN
  • 2169-1401 (ISSN-L)
  • 2169-141X
DOI
10.1080/21691401.2021.1883043
OpenAlex
W4220666443
Cited by
19
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 9 · 2023: 4
FWCI
3.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Artificial Cells Nanomedicine and Biotechnology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute for Medical Research and Development (957687)
Topics
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
peritoneal adhesions, postoperative adhesion prevention, ibuprofen, silk fibroin, polyethylene glycol, electrospinning, adhesion prevention, anti-inflammatory agents, drug release, membrane degradation, rat model, abdominal wall closure
MeSH terms
Tissue Adhesions, Animals, Female, Ibuprofen, Membranes, Artificial, Silk, Rats, Nanofibers

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