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Are adenoviruses zoonotic? A systematic review of the evidence
Open accessAbstract
Adenoviruses (AdVs) are major contributors to clinical illnesses. Novel human and animal AdVs continue to be identified and characterized. Comparative analyses using bioinformatic methods and Omics-based technologies allow insights into how these human pathogens have emerged and their potential for host cross-species transmission. Systematic review of literature published across ProQuest, Pubmed, and Web of Science databases for evidence of adenoviral zoonotic potential identified 589 citations. After removing duplicates, 327 citations were screened for relevance; of which, 74 articles received full-text reviews. Among these, 24 were included here, of which 16 demonstrated evidence of zoonotic transmission of AdVs. These documented instances of AdV crossing host species barriers between humans and non-human primate, bat, feline, swine, canine, ovine, and caprine. Eight studies sought to but did not find evidence of zoonosis. The findings demonstrate substantial evidence suggesting AdVs have previously and will continue crossing host species barriers. These have human health consequences both in terms of novel pathogen emergence and epidemic outbreaks, and of appropriate and safe use of non-human adenoviruses for therapeutics. As routine human clinical diagnostics may miss a novel cross-species adenovirus infection in humans, next generation sequencing or panspecies molecular diagnostics may be necessary to detect such incursions.
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“No suitable tool for assessing noncomparative studies could be found in the literature and similar systematic reviews of human-to-human or animal-to-human transmission of infectious agents that we could find did not undertake a RoB assessment [21–24].”
From Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review (2022) · cites this paper as [24]
The Methods section describes a literature search and study screening, but does not discuss whether a suitable risk-of-bias tool for noncomparative studies exists. Searches for risk-of-bias tools and quality assessment found no passage addressing that claim. (LLM, conf=0.72)
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Evidence for Human-to-Human Transmission of Hantavirus: A Systematic Review
Toledo, J., Haby, M. M., Reveiz, L., Sosa Leon, L., Angerami, R., & Aldighieri, S. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab461 · Cited by 78
Metadata
- Authors
- Borkenhagen, L. K., Fieldhouse, J. K., Seto, D., & Gray, G. C.
- Affiliations
- Duke University (US)
- George Mason University (US)
- Corresponding author
- Gray, Gregory C.
- Venue
- Emerging Microbes & Infections
- Publisher
- Informa UK Limited
- Published
- 2019-01
- Volume
- 8
- Issue
- 1
- Pages
- 1679-1687
- ISSN
- 2222-1751 (ISSN-L)
- PMC
- PMC6882429
- OpenAlex
- W2990203560
- Cited by
- 79
- References
- 63
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 18 · 2023: 10 · 2022: 13 · 2021: 9 · 2020: 8
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Emerging Microbes & Infections (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Duke Global Health Institute, Duke University
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Zoonotic diseases and public health
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- adenovirus, zoonotic transmission, interspecies transmission, non-human primates, bats, canine adenovirus, emerging pathogens, molecular diagnosis
- MeSH terms
- Adenoviridae, Adenoviridae Infections, Animals, Cats, Dogs, Goats, Humans, Phylogeny, Sheep, Swine, Zoonoses, Host Specificity
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