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Emergence of oxacillinase-181 carbapenemase-producing diarrheagenic Escherichia coli in Ghana
Open accessAbstract
The emergence and spread of carbapenemase-producing bacteria are serious threats to public health. We characterized two OXA-181-producing Escherichia coli isolates from pediatric patients with diarrhea from Ghana. blaOXA-181 was localized on the self-conjugative IncX3-containing plasmid in the E. coli ST410 isolate, belonging to an emerging lineage, and an IncFIC(FII)-containing plasmid in E. coli ST940. The blaOXA-181-qnrS1 region was found on the IS26 composite transposon, which contained a 366-bp deletion in the region encoding the Rep A protein for the IncX3-containing plasmid. The IncFIC(FII) plasmid was novel and integrated with an approximately 39-kb IncX1 plasmid through conjugal transfer. Both plasmids clustered close to plasmids from Switzerland. To the best of our knowledge, this is the first report describing the presence of an IncX3 plasmid containing blaOXA-181 in strains closely related to the B4/H24RxC clade in Africa, suggesting its emergence and the need to strengthen antimicrobial resistance surveillance.
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Carbapenemase-encoding genes have been observed among diarrheagenic Escherichia coli isolates in several countries in the sub-Saharan Africa region.
“Of concern are carbapenemase-encoding genes, which have been observed among diarrheagenic E. coli isolates in several countries in the region.”
From Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? (2022) · cites this paper as [47]
The Results (Antimicrobial susceptibility and β-lactamase-encoding gene screening) identify a carbapenemase gene in one diarrheagenic E. coli isolate, and the Methods (Bacterial strains) place the isolates in Ghana. The paper does not report such findings in several sub-Saharan African countries; the other gene-positive isolate was non-diarrheagenic. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn Ghana and Burkina Faso, ST410 diarrheagenic Escherichia coli isolates were reported to have the blaOXA-181 gene contained in an IncX3 plasmid.
“For instance, in Ghana 47 and Burkina Faso, 46 ST410 diarrheagenic E. coli isolates were reported to have the blaOXA-181 gene (a variant of the class D blaOXA-48), which was contained in an IncX3 plasmid.”
From Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? (2022) · cites this paper as [47]
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Bruzzese, E., Giannattasio, A., & Guarino, A. (2018) · F1000Research · doi:10.12688/f1000research.12328.1 · Cited by 122
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Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now?
Kariuki, S., Kering, K., Wairimu, C., Onsare, R., & Mbae, C. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s342753 · Cited by 245
Metadata
- Authors
- Prah, I., Ayibieke, A., Mahazu, S., Sassa, C. T., Hayashi, T., Yamaoka, S., Suzuki, T., Iwanaga, S., Ablordey, A., & Saito, R.
- Affiliations
- Tokyo Medical and Dental University (JP)
- University of Ghana (GH)
- Corresponding author
- Saito, Ryoichi
- ORCID
- Venue
- Emerging Microbes & Infections
- Publisher
- Informa UK Limited
- Published
- 2021-01-01
- Volume
- 10
- Issue
- 1
- Pages
- 865-873
- ISSN
- 2222-1751 (ISSN-L)
- PMC
- PMC8110189
- OpenAlex
- W3155589090
- Cited by
- 27
- References
- 1
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 7 · 2023: 1 · 2022: 10 · 2021: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Emerging Microbes & Infections (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ohyama Health Foundation
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Keywords
- carbapenemase, diarrheagenic Escherichia coli, IncX3 plasmid, IncX1 plasmid, qnrS1, childhood diarrhea, antimicrobial resistance surveillance, Ghana
- MeSH terms
- Whole Genome Sequencing, Anti-Bacterial Agents, beta-Lactamases, Diarrhea, Escherichia coli, Escherichia coli Infections, Ghana, Humans, Microbial Sensitivity Tests, Escherichia coli Proteins
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