Aspergillus fumigatus cell wall: composition and biosynthesis
Abstract
Analysis of the cell wall of Aspergillus fumigatus is guided by obvious biological reasons: the cell wall protects the fungus against the aggressive human defense reactions, it harbours most of the fungal antigens and it represents a potential drug target. This review will discuss our current understanding of the structural organization of the polysaccharides constitutive of the cell wall of A. fumigatus [alpha and beta(1,3)-glucans, chitin, galactomannan, and beta(1,3),(1,4)-glucan] and of the enzymes (synthases, transglycosidases, and glycosyl hydrolases) responsible for their biosynthesis and remodelling. Comparative analysis of the cell wall of the conidium and mycelium also provides insights on their respective roles during the pathogenic life of this fungal species.
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The use of chromogenic culture media (CHROMagar Candida or equivalent) in the laboratory can help distinguish C. albicans from several common Candida species other than C. albicans and can serve an important role in rapid species identification prior to the completion of antifungal susceptibility testing.
“The use of chromogenic culture media (CHROMagar Candida or equivalent) (11, 15) in the laboratory can help distinguish C. albicans from several common Candida species other than C. albicans and can serve an important role in rapid species identification prior to the completion of antifungal susceptibility testing.”
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References 34 · Cited by 282
Research works printed but not linked: 2
- Mouyna I, Hartland RP, Fontaine T, Diaquin M, Latge ´JP. A b (1-3) glucanosyltransferase isolated from the cell wall of Aspergillus fumigatus is an homolog of the yeast Bgl2p. Microbiolgy 1998; 144: 3171-3180.
- Bruneau JM, Magnin T, Tagat E, Legrand R, Bernard M, Diaquin M, Fudali C, Latge ´JP. Proteome analysis of Aspergillus fumigatus identi es glycosylphosphatidylino-sitol- anchored proteins associated to the cell wall biosynthesis. Electrophoresis 2001; 22: 2812-2823.
- Authors
- Bernard, M., & Latgé, J.-P.
- Affiliations
- Institut Pasteur (FR)
- Corresponding author
- Latgé, J.-P.
- ORCID
- Latgé, J.-P.
- Venue
- Medical Mycology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-01
- Volume
- 39
- Issue
- 1
- Pages
- 9-17
- ISSN
- 0268-1218 (ISSN-L)
- 1369-3786
- 1460-2709
- OpenAlex
- W2138738780
- Cited by
- 282
- References
- 34
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 15 · 2018: 10 · 2017: 18 · 2016: 8 · 2015: 13 · 2014: 16 · 2013: 11 · 2012: 15
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Mycology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Aspergillus fumigatus, fungal cell wall, cell wall composition, cell wall biosynthesis, β-1,3-glucan, chitin, galactomannan, glycoside hydrolases, mycelium, fungal pathogenicity, therapeutic target
- MeSH terms
- Aspergillus fumigatus, Cell Wall, Chitin, Glucans, Melanins, Mycelium
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