Treatment of heroin dependence with buprenorphine in primary care
Abstract
Buprenorphine is an effective treatment for heroin dependence. The feasibility and potential efficacy of buprenorphine with brief counseling in primary care is unknown. We enrolled 14 heroin dependent patients in a 13-week clinical trial using thrice weekly buprenorphine along with brief counseling in the primary care center of an urban medical center. Primary outcomes included urine toxicology and treatment retention. Opioid-positive urine toxicology tests reduced over the 13-week period from 95 to 25% (p < 0.05). Eleven patients (79%) had greater than or equal to one week of opioid-free urine toxicologies. Nine patients (64%) had greater than or equal to three weeks of opioid-free urine toxicologies. Eleven patients (79%) were retained through the maintenance phase. We conclude that buprenorphine maintenance is feasible in a primary care setting.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Office-based buprenorphine/naloxone treatment has demonstrated efficacy.
“This paucity of research is particularly noteworthy given the increasing availability and demonstrated efficacy of office-based buprenorphine/naloxone treatment.5–7”
From Patient Satisfaction with Primary Care Office-Based Buprenorphine/Naloxone Treatment (2007) · cites this paper as [6]
The citation lists haven’t been fetched yet
References 27 · Cited by 98
- Authors
- Fiellin, D. A., Pantalon, M. V., Pakes, J. P., O'Connor, P. G., Chawarski, M., & Schottenfeld, R. S.
- Affiliations
- Yale University (US)
- Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St., P.O. Box 208025, New Haven, CT, 06520-8025, U.S.A.
- Venue
- The American Journal of Drug and Alcohol Abuse
- Publisher
- Informa UK Limited
- Published
- 2002-01-01
- Volume
- 28
- Issue
- 2
- Pages
- 231-241
- ISSN
- 0095-2990 (ISSN-L)
- 1097-9891
- OpenAlex
- W2118988525
- Cited by
- 98
- References
- 27
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Drug and Alcohol Abuse (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- National Institute on Drug Abuse (K12DA000167)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- heroin addiction, buprenorphine, opioid substitution therapy, primary care, brief counseling, treatment retention, urine toxicology, feasibility, maintenance therapy
- MeSH terms
- Administration, Sublingual, Adult, Ambulatory Care, Buprenorphine, Combined Modality Therapy, Connecticut, Counseling, Dose-Response Relationship, Drug, Drug Administration Schedule, Feasibility Studies, Female, Heroin Dependence, Humans, Male, Middle Aged, Primary Health Care, Social Support, Urban Population, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
