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Role of Human Aldehyde Dehydrogenases in Endobiotic and Xenobiotic Metabolism
Abstract
The human genome contains at least 17 genes that are members of the aldehyde dehydrogenase (ALDH) superfamily. These genes encode NAD(P)(+)-dependent enzymes that oxidize a wide range of aldehydes to their corresponding carboxylic acids. Aldehydes are highly reactive molecules that are intermediates or products involved in a broad spectrum of physiologic, biologic, and pharmacologic processes. Aldehydes are generated during retinoic acid biosynthesis and the metabolism of amino acids, lipids, carbohydrates, and drugs. Mutations in several ALDH genes are the molecular basis of inborn errors of metabolism and contribute to environmentally induced diseases.
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Duester, G. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01497.x · Cited by 570
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Metadata
- Authors
- Vasiliou, V., Pappa, A., & Estey, T.
- Venue
- Drug Metabolism Reviews
- Publisher
- Informa UK Limited
- Published
- 2004-01
- Volume
- 36
- Issue
- 2
- Pages
- 279-299
- ISSN
- 0360-2532 (ISSN-L)
- 1097-9883
- OpenAlex
- W2136456223
- Cited by
- 308
- References
- 1
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vasiliou, V., Pappa, A., & Estey, T. (2004). Role of Human Aldehyde Dehydrogenases in Endobiotic and Xenobiotic Metabolism. Drug Metabolism Reviews. https://doi.org/10.1081/dmr-120034001
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