The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability Transition
Abstract
Large doses of the analgesic acetaminophen cause centrilobular hepatic necrosis in man and in experimental animals. It has been previously shown that acetaminophen is metabolically activated by CYP enzymes to N-acetyl-p-benzoquinone imine. This species is normally detoxified by GSH, but following a toxic dose GSH is depleted and the metabolite covalently binds to a number of different proteins. Covalent binding occurs only to the cells developing necrosis. Recently we showed that these cells also contain nitrated tyrosine residues. Nitrotyrosine is mediated by peroxynitrite, a reactive nitrogen species formed by rapid reaction between nitric oxide and superoxide and is normally detoxified by GSH. Thus, acetaminophen toxicity occurs with increased oxygen/nitrogen stress. This manuscript will review current data on acetaminophen covalent binding, increased oxygen/nitrogen stress, and mitochondrial permeability transition, a toxic mechanism that is both mediated by and leads to increased oxygen/nitrogen stress.
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ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. IV. PROTECTIVE ROLE OF GLUTATHIONE
Mitchell, J. R., Jollow, D. J., Potter, W. Z., Gillette, J. R., & Brodie, B. B. (1973) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29666-5 · Cited by 1,737
ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM
Mitchell, J. R., Jollow, D. J., Potter, W. Z., Davis, D. C., Gillette, J. R., & Brodie, B. B. (1973) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29663-x · Cited by 1,498
ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. II. ROLE OF COVALENT BINDING IN VIVO
Jollow, D. J., Mitchell, J. R., Potter, W. Z., Davis, D. C., Gillette, J. R., & Brodie, B. B. (1973) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29664-1 · Cited by 1,204
Role of metals in oxygen radical reactions
Aust, S. D., Morehouse, L. A., & Thomas, C. E. (1985) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/0748-5514(85)90025-x · Cited by 1,145
Acetaminophen-induced Hepatic Necrosis
Jollow, D. J., Thorgeirsson, S. S., Potter, W. Z., Hashimoto, M., & Mitchell, J. R. (1974) · Pharmacology · doi:10.1159/000136547 · Cited by 1,092
N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.
Dahlin, D. C., Miwa, G. T., Lu, A. Y., & Nelson, S. D. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.5.1327 · Cited by 1,078
ACETAMINOPHEN-INDUCED HEPATOTOXICITY
James, L. P., Mayeux, P. R., & Hinson, J. A. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.12.1499 · Cited by 1,033
Self-citationOxidative Damage and Tyrosine Nitration from Peroxynitrite
Beckman, J. S. (1996) · Chemical Research in Toxicology · doi:10.1021/tx9501445 · Cited by 992
Mitochondrial permeability transition: a common pathway to necrosis and apoptosis
Kim, J.-S., He, L., & Lemasters, J. J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00618-1 · Cited by 755
Bessems, J. G. M., & Vermeulen, N. P. E. (2001) · Critical Reviews in Toxicology · doi:10.1080/20014091111677 · Cited by 715
Cited by
Mechanisms of Acetaminophen-Induced Liver Necrosis
Hinson, J. A., Roberts, D. W., & James, L. P. (2010) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-00663-0_12 · Cited by 1,006
Self-citationJaeschke, H., McGill, M. R., & Ramachandran, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.602688 · Cited by 964
Biological effects of gum arabic: A review of some recent research
Ali, B. H., Ziada, A., & Blunden, G. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.07.001 · Cited by 486
Larson, A. M. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.06.006 · Cited by 451
The significance of mitochondrial toxicity testing in drug development
Dykens, J. A., & Will, Y. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.07.013 · Cited by 416
Metadata
- Authors
- Hinson, J. A., Reid, A. B., McCullough, S. S., & James, L. P.
- Venue
- Drug Metabolism Reviews
- Publisher
- Informa UK Limited
- Published
- 2004-01
- Volume
- 36
- Issue
- 3-4
- Pages
- 805-822
- ISSN
- 0360-2532 (ISSN-L)
- 1097-9883
- OpenAlex
- W2029226467
- Cited by
- 306
- References
- 100
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hinson, J. A., Reid, A. B., McCullough, S. S., & James, L. P. (2004). Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability Transition. Drug Metabolism Reviews. https://doi.org/10.1081/dmr-200033494
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