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RELATIONSHIP BETWEEN RENAL FUNCTION AND BLOOD LEVEL OF CHROMOGRANIN A
Open accessAbstract
Chromogranin A (CGA) is a low MW (49,000) acidic hydrophilic protein. It is synthesized in the chromaffm granules of the neuroendocrine cells, and has been found circulating in the blood of healthy subjects. The aim of this study was to assess the relationship between serum levels of CGA and renal function. One hundred two renal patients (45 M and 57 F; age 14-76 years, mean 52) participated in the study. Glomerular filtration rate (GFR) was measured by the bladder cumulative method, using 99mTc-DTPA as a tracer. Blood CGA was determined by RIA. Plasma creatinine, beta2microglobulin (beta2m) and tumor associated trypsin inhibitor (TATI) were also determined. The reduction in renal function was associated with an increase in all of the above studied parameters. In patients with advanced renal failure (GFR <20 mL/min) CGA levels increased by 22-fold as compared to the patients with normal renal function (GFR> 100 mL/min). The other studied parameters were also increased but to a lesser degree, e.g., TATI 14-, beta2m 8- and creatinine 5-fold. The results of this study demonstrate that renal handling of the CGA is similar to other low MW proteins, and it accumulates in the blood in renal failure.
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“Chromogranin A levels may also be elevated in other disease processes, such as prostate cancer, liver failure, cardiovascular diseases and renal failure (Tramonti et al, 2001; Modlin et al, 2010; Vezzosi et al, 2011).”
From Discontinuation of proton pump inhibitors during assessment of chromogranin A levels in patients with neuroendocrine tumours (2011) · cites this paper as Tramonti et al, 2001
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References 34 · Cited by 48
Research works printed but not linked: 3
- Docci D, 1987, Clinical Nephrology, 27, 179
- Tramonti G, 1997, Kidney Int, 52, S179
- Bianchi C, 1992, Nephrologie, 13, 221
Metadata
- Authors
- Tramonti, G., Ferdeghini, M., Annichiarico, C., Norpoth, M., Donadio, C., Bianchi, R., & Bianchi, C.
- Affiliations
- University of Pisa (IT)
- ORCID
- Donadio, Carlo
- Venue
- Renal Failure
- Publisher
- Informa UK Limited
- Published
- 2001-01
- Volume
- 23
- Issue
- 3-4
- Pages
- 449-457
- ISSN
- 0886-022X (ISSN-L)
- 1525-6049
- OpenAlex
- W2123100589
- Cited by
- 48
- References
- 34
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Renal Failure (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- chromogranin A, renal function, glomerular filtration rate, serum protein levels, low molecular weight proteins, beta2-microglobulin, tumor-associated trypsin inhibitor, creatinine
- MeSH terms
- Adolescent, Adult, Aged, beta 2-Microglobulin, Chromogranins, Creatinine, Female, Glomerular Filtration Rate, Humans, Kidney Diseases, Kidney Function Tests, Male, Middle Aged, Trypsin Inhibitor, Kazal Pancreatic, Biomarkers, Tumor, Chromogranin A
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- CoChat. (2026). Citation check: RELATIONSHIP BETWEEN RENAL FUNCTION AND BLOOD LEVEL OF CHROMOGRANIN A. https://app.cochat.ai/papers/10.1081/jdi-100104728
- The paper
- Tramonti, G., Ferdeghini, M., Annichiarico, C., Norpoth, M., Donadio, C., Bianchi, R., & Bianchi, C. (2001). RELATIONSHIP BETWEEN RENAL FUNCTION AND BLOOD LEVEL OF CHROMOGRANIN A. Renal Failure. https://doi.org/10.1081/jdi-100104728
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
