The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Localization of topoisomerase II in mitotic chromosomes.
Open accessAbstract
In the preceding article we described a polyclonal antibody that recognizes cSc-1, a major polypeptide component of the chicken mitotic chromosome scaffold. This polypeptide was shown to be chicken topoisomerase II. In the experiments described in the present article we use indirect immunofluorescence and immunoelectron microscopy to examine the distribution of topoisomerase II within intact chromosomes. We also describe a simple experimental protocol that differentiates antigens that are interspersed along the chromatin fiber from those that occupy restricted domains within the chromosome. These experiments indicate that the distribution of the enzyme appears to be independent of the bulk chromatin. Our data suggest that topoisomerase II is bound to the bases of the radial loop domains of mitotic chromosomes.
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Citations
Cites
Tewey, K. M., Chen, G. L., Nelson, E. M., & Liu, L. F. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)47282-6 · Cited by 887
Cited by
A pathway for mitotic chromosome formation
Gibcus, J. H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M. T., Xie, L., Paulson, J. R., Earnshaw, W. C., et al. (2018) · Science · doi:10.1126/science.aao6135 · Cited by 744
Self-citationMetaphase chromosome structure
Gasser, S. M., Laroche, T., Falquet, J., Boy de la Tour, E., & Laemmli, U. K. (1986) · Journal of Molecular Biology · doi:10.1016/s0022-2836(86)80010-9 · Cited by 536
A glimpse at chromosomal order
Gasser, S. M., & Laemmli, U. K. (1987) · Trends in Genetics · doi:10.1016/0168-9525(87)90156-9 · Cited by 408
Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice
Fortune, J. M., & Osheroff, N. (2000) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(00)64006-0 · Cited by 366
Newport, J., & Spann, T. (1987) · Cell · doi:10.1016/0092-8674(87)90425-9 · Cited by 344
Metadata
- Authors
- Earnshaw, W. C., & Heck, M. M.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1985-05-01
- Volume
- 100
- Issue
- 5
- Pages
- 1716-1725
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2110479470
- Cited by
- 495
- References
- 1
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Earnshaw, W. C., & Heck, M. M. (1985). Localization of topoisomerase II in mitotic chromosomes. The Journal of cell biology. https://doi.org/10.1083/jcb.100.5.1716
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
