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Inhibition of endothelial cell proliferation by gamma-interferon.
Open accessAbstract
Endothelial cell growth factor (ECGF) is a potent polypeptide mitogen for endothelial cells and fibroblasts. The mitogenic effects of ECGF are inhibited by the lymphokine gamma-interferon (gamma-IFN) in a dose-dependent manner. Gamma-IFN also induces a unique change in endothelial cell morphology which is maximally expressed in the presence of ECGF. The antiproliferative and phenotypic modulatory effects of gamma-IFN on endothelial cells are reversible. Inhibition of ECGF-induced endothelial cell proliferation by gamma-IFN is accompanied by a concentration- and time-dependent decrease in binding of 125I-ECGF to the endothelial cell surface. Scatchard analyses of the binding data in the presence and absence of gamma-IFN demonstrate a decrease in the number of ECGF-binding sites rather than a decrease in ligand affinity for the receptor. Cross-linking experiments with disuccinimidyl suberate demonstrate a decrease in the 170,000 Mr cross-linked receptor-ligand complex. These data suggest that gamma-IFN inhibits endothelial cell proliferation by a mechanism which involves growth factor receptor modulation.
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Citations
Cited by
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Papetti, M., & Herman, I. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2001 · Cited by 809
Chen, P.-Y., Qin, L., Barnes, C., Charisse, K., Yi, T., Zhang, X., Ali, R., Medina, P. P., Yu, J., Slack, F. J., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.021 · Cited by 304
Metadata
- Authors
- Friesel, R., Komoriya, A., & Maciag, T.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1987-03-01
- Volume
- 104
- Issue
- 3
- Pages
- 689-696
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2037932608
- Cited by
- 287
- References
- 0
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Friesel, R., Komoriya, A., & Maciag, T. (1987). Inhibition of endothelial cell proliferation by gamma-interferon. The Journal of cell biology. https://doi.org/10.1083/jcb.104.3.689
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