The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies
Open accessAbstract
We have developed video microscopy methods to visualize the assembly and disassembly of individual microtubules at 33-ms intervals. Porcine brain tubulin, free of microtubule-associated proteins, was assembled onto axoneme fragments at 37 degrees C, and the dynamic behavior of the plus and minus ends of microtubules was analyzed for tubulin concentrations between 7 and 15.5 microM. Elongation and rapid shortening were distinctly different phases. At each end, the elongation phase was characterized by a second order association and a substantial first order dissociation reaction. Association rate constants were 8.9 and 4.3 microM-1 s-1 for the plus and minus ends, respectively; and the corresponding dissociation rate constants were 44 and 23 s-1. For both ends, the rate of tubulin dissociation equaled the rate of tubulin association at 5 microM. The rate of rapid shortening was similar at the two ends (plus = 733 s-1; minus = 915 s-1), and did not vary with tubulin concentration. Transitions between phases were abrupt and stochastic. As the tubulin concentration was increased, catastrophe frequency decreased at both ends, and rescue frequency increased dramatically at the minus end. This resulted in fewer rapid shortening phases at higher tubulin concentrations for both ends and shorter rapid shortening phases at the minus end. At each concentration, the frequency of catastrophe was slightly greater at the plus end, and the frequency of rescue was greater at the minus end. Our data demonstrate that microtubules assembled from pure tubulin undergo dynamic instability over a twofold range of tubulin concentrations, and that the dynamic instability of the plus and minus ends of microtubules can be significantly different. Our analysis indicates that this difference could produce treadmilling, and establishes general limits on the effectiveness of length redistribution as a measure of dynamic instability. Our results are consistent with the existence of a GTP cap during elongation, but are not consistent with existing GTP cap models.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“indicating that a higher tubulin concentration and, consequently, a higher MT growth rate have a catastrophe-suppressing effect, in line with previously published data [20]”
From In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends (2010) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Morrissey, J. H. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90783-1 · Cited by 4,061
Dynamic instability of microtubule growth
Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337
Merril, C. R., Goldman, D. A., Sedman, S. A., & Ebert, M. H. (1981) · Science · doi:10.1126/science.6162199 · Cited by 2,933
An Introduction to Error Analysis
Taylor, J. R. (1982) · Medical Entomology and Zoology · Cited by 2,807
Microtubule assembly nucleated by isolated centrosomes
Mitchison, T. J., & Kirschner, M. W. (1984) · Nature · doi:10.1038/312232a0 · Cited by 779
Head to tail polymerization of actin
Wegner, A. (1976) · Journal of Molecular Biology · doi:10.1016/s0022-2836(76)80100-3 · Cited by 716
Visualization of the dynamic instability of individual microtubules by dark-field microscopy
Horio, T., & Hotani, H. (1986) · Nature · doi:10.1038/321605a0 · Cited by 565
ALLEN, R. D., Allen, N. S., & Travis, J. L. (1981) · Cell Motility · doi:10.1002/cm.970010303 · Cited by 419
Sites of microtubule assembly and disassembly in the mitotic spindle
Mitchison, T. J., Evans, L., Schulze, E., & Kirschner, M. W. (1986) · Cell · doi:10.1016/0092-8674(86)90283-7 · Cited by 415
Gard, D. L., & Kirschner, M. W. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.5.2203 · Cited by 354
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–800 of 979
Numerical Parameter Space Compression and Its Application to Biophysical Models
Hsu, C.-T., Brouhard, G. J., & François, P. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.01.023 · Cited by 9
The regulatory effect of Tau protein on polymerization of MCF7 microtubules in vitro
Feizabadi, M. S., Hernandez, M. A. V., Breslin, J., & Akintola, I. I. (2019) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2018.12.010 · Cited by 8
Watching microtubules grow one tubulin at a time
Гудимчук, Н. Б., & Roll‐Mecak, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902991116 · Cited by 8
Salmon, E. D., Yeh, E., Shaw, S. L., Skibbens, B., & Bloom, K. (1998) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(98)98028-4 · Cited by 8
Self-citationPotential Roles of Microtubule Associated Motor Molecules in Cell Divisiona
Vallee, R. B., Shpetner, H. S., & Paschal, B. M. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb21671.x · Cited by 8
n-ethylmaleimide and ethacrynic acid inhibit kinesin binding to microtubules in a motility assay
Walker, R. A., O’Brien, E. T., Epstein, D. L., & Sheetz, M. P. (1997) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(1997)37:4 · Cited by 8
Self-citationLarge fluctuations in the disassembly rate of microtubules revealed by atomic force microscopy
Thomson, N. H., Kasas, S., Riederer, B. M., Catsicas, S., Dietler, G., Kulik, A., & Laszlo Forro, C. (2003) · Ultramicroscopy · doi:10.1016/s0304-3991(03)00048-2 · Cited by 8
Tracking the Motion of the Outer Tips of Microtubules
Hadjidemetriou, S., Toomre, D. K., & Duncan, J. S. (2006) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi.2006.1624970 · Cited by 8
Grimaldi, A. D., Žanić, M., & Kaverina, I. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1026521 · Cited by 9
Disruption of microtubules in living cells by tyrphostin AG-1714
Volberg, T., Bershadsky, A. D., Elbaum, M., Gazit, A., Levitzki, A., & Geiger, B. (2000) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(200003)45:3 · Cited by 7
Characterization of Three Fusarium spp. Causing Wilt Disease of Cannabis sativa L. in Korea
Koo, Y. M., Ahsan, S. M., & Choi, H. W. (2023) · Mycobiology · doi:10.1080/12298093.2023.2213911 · Cited by 7
Ase1 selectively increases the lifetime of antiparallel microtubule overlaps
Krattenmacher, J., Lera-Ramírez, M., Beber, A., Herynek, Š., Grycová, L., Liu, X., Neužil, P., Nédélec, F., Diez, S., Braun, M., et al. (2024) · Current Biology · doi:10.1016/j.cub.2024.07.055 · Cited by 7
Cooperative motor action to regulate microtubule length dynamics
Verma, A. K., Sharma, N., & Gupta, A. K. (2019) · Physical review. E · doi:10.1103/physreve.99.032411 · Cited by 7
Dynamic microtubules slow down during their shrinkage phase
Łuchniak, A., Kuo, Y., McGuinness, C., Sutradhar, S., Orbach, R., Mahamdeh, M., & Howard, J. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.01.020 · Cited by 11
Interface-acting nucleotide controls polymerization dynamics at microtubule plus- and minus-ends
McCormick, L. A., Cleary, J. M., Hancock, W. O., & Rice, L. M. (2023) · eLife · doi:10.7554/elife.89231 · Cited by 7
Growth and Shortening of Microtubules
Zhang, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.260208 · Cited by 7
Measuring the persistence length of MCF7 cell microtubules in vitro
Feizabadi, M. S., Mutafopulos, K. S., & Behr, A. (2011) · Biotechnology Journal · doi:10.1002/biot.201000465 · Cited by 7
Model of Growth Cone Membrane Polarization via Microtubule Length Regulation
Xu, B., & Bressloff, P. C. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.09.019 · Cited by 7
High-Resolution Video-Enhanced Differential Interference Contrast Light Microscopy
Salmon, E. D., & Tran, P. T. (2003) · Methods in cell biology · doi:10.1016/s0091-679x(03)72014-7 · Cited by 7
Self-citationLessons from in vitro reconstitution analyses of plant microtubule-associated proteins
Hamada, T. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00409 · Cited by 8
Microtubule dynamics inXenopus egg extracts
Shirasu‐Hiza, M., Yonetani, A., & Walczak, C. (1999) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19990315)44:6 · Cited by 7
Microtubule Dynamics: Bioenergetics and Control
Purich, D. L., & Angelastro, J. M. (1994) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470123157.ch4 · Cited by 7
Should the Tubulins be Members of the GTPase Superfamily?
Burns, R. G., Farrell, K., & Surridge, C. D. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514450.ch16 · Cited by 7
Liu, H., Yamaguchi, H., Kikkawa, M., & Shima, T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.30.591984 · Cited by 8
Kuo, Y., & Howard, J. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1983-4_5 · Cited by 6
Microtubule: a dynamically unstable stochastic phase switching polymer
Zakharov, P. N., Arzhanik, V. K., Ulyanov, E. V., Гудимчук, Н. Б., & Ataullakhanov, F. I. (2016) · Uspekhi Fizicheskih Nauk · doi:10.3367/ufnr.2016.04.037779 · Cited by 6
Lee, S., Bashir, K. M. I., Jung, D. H., Basu, S. K., Seo, G., Cho, M.-G., & Wierschem, A. (2022) · Interface Focus · doi:10.1098/rsfs.2022.0036 · Cited by 5
Modeling the effects of drug binding on the dynamic instability of microtubules
Hinow, P., Rezania, V., Lopus, M., Jordan, M. A., & Tuszyński, J. A. (2011) · Physical Biology · doi:10.1088/1478-3975/8/5/056004 · Cited by 6
Active Biopolymers Confer Fast Reorganization Kinetics
Swanson, D., & Wingreen, N. S. (2011) · Physical Review Letters · doi:10.1103/physrevlett.107.218103 · Cited by 6
pH‐Dependent solubility and assembly of microtubules in bovine brain extracts
Tiwari, S. C., & Suprenant, K. A. (1994) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970280107 · Cited by 6
High-Pressure Microscopy for Studying Molecular Motors
Nishiyama, M. (2015) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9918-8_27 · Cited by 6
TubZ filament assembly dynamics requires the flexible C-terminal tail
Fuentes-Perez, M. E., Núñez‐Ramírez, R., Martín-González, A., Juan-Rodríguez, D., Llorca, Ó., Moreno‐Herrero, F., & Oliva, M. A. (2017) · Scientific Reports · doi:10.1038/srep43342 · Cited by 6
In Vitro Microtubule Dynamics Assays Using Dark-Field Microscopy
Spector, J. O., Vemu, A., & Roll‐Mecak, A. (2019) · Methods in molecular biology · doi:10.1007/978-1-0716-0219-5_4 · Cited by 6
Evolution of research on cellular motility over five decades
Pollard, T. D. (2018) · Biophysical Reviews · doi:10.1007/s12551-018-0473-9 · Cited by 6
Mauro, A. J., Jonasson, E. M., & Goodson, H. V. (2019) · Cytoskeleton · doi:10.1002/cm.21557 · Cited by 6
Stochastic Model of T Cell Repolarization during Target Elimination I
Hornak, I., & Rieger, H. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.01.045 · Cited by 6
Shelden, & Knecht, D. A. (1998) · Journal of Microscopy · doi:10.1046/j.1365-2818.1998.00352.x · Cited by 6
N -Ethylmaleimide Inhibits Ncd Motor Function by Modification of a Cysteine in the Stalk Domain
PHELPS, K. K., & Walker, R. A. (1999) · Biochemistry · doi:10.1021/bi990706+ · Cited by 6
Self-citationMicrotubule dynamics in a cytosolic extract of fetal rat brain
Simon, J. R., Graff, R. D., & Maness, P. F. (1998) · Journal of Neurocytology · doi:10.1023/a:1006999306413 · Cited by 6
Opposite-end behaviour of dynamic microtubules
Martin, S. R., Schilstra, M. J., & Bayley, P. M. (1991) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(91)90230-e · Cited by 6
Cell motility and the cytoskeleton video supplement 2. Video tape contents
(1990) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970170410 · Cited by 6
Control of microtubule polymerization and stability
Ávila, J., & Díaz‐Nido, J. (1995) · The Cytoskeleton · doi:10.1016/s1874-6020(06)80005-4 · Cited by 6
Effect of curvature and normal forces on motor regulation of ciliaPreprint
Sartori, P. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1905.04138 · Cited by 6
Phase separation of microtubule-binding proteins – implications for neuronal function and disease
Duan, D., & Koleske, A. J. (2024) · Journal of Cell Science · doi:10.1242/jcs.263470 · Cited by 5
Mechanism of the Initial Tubulin Nucleation Phase
Shemesh, A., Dharan, N., Ginsburg, A., Dharan, R., Levi‐Kalisman, Y., Ringel, I., & Raviv, U. (2022) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.2c02619 · Cited by 5
Preparation of Dual-Color Polarity-Marked Fluorescent Microtubule Seeds
Katsuki, M., Muto, E., & Cross, R. A. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-252-6_9 · Cited by 5
Dendrite and Axon Specific Geometrical Transformation in Neurite Development
Mironov, V. I., Semyanov, A. V., & Kazantsev, V. (2016) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2015.00156 · Cited by 5
Barlukova, A., White, D., Henry, G., Honoré, S., & Hubert, F. (2017) · ESAIM Mathematical Modelling and Numerical Analysis · doi:10.1051/m2an/2017025 · Cited by 5
Portran, D. (2014) · Methods in cell biology · doi:10.1016/b978-0-12-417136-7.00003-3 · Cited by 5
Persistent growth of microtubules at low density
Burakov, A. V., Vorobjev, I. A., Semenova, I., Cowan, A. E., Carson, J. H., Wu, Y., & Rodionov, V. (2021) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-08-0546 · Cited by 6
Petek-Seoane, N. A., Rodriguez, J., Derman, A. I., Royal, S. G., Lord, S. J., Lawrence, R. E., Pogliano, J., & Mullins, R. D. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-11-0440 · Cited by 5
Is actin filament and microtubule growth reaction- or diffusion-limited?
Pausch, J., & Pruessner, G. (2019) · Journal of Statistical Mechanics Theory and Experiment · doi:10.1088/1742-5468/ab081c · Cited by 5
Charlebois, B. D., Schek, H. T., & Hunt, A. J. (2010) · Methods in cell biology · doi:10.1016/s0091-679x(10)95012-7 · Cited by 5
Kurachi, M., Kikumoto, M., Tashiro, H., Komiya, Y., & Tashiro, T. (1999) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(1999)42:2 · Cited by 5
Different protofilament-dependence of the microtubule binding between MAP2 and MAP4
Kawachi, A., Ichihara, K., Hisanaga, S., Iida, J., Toyota, H., Hotani, H., & Itoh, T. J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00707-1 · Cited by 5
NCD activation of tubulin polymerization
Highsmith, S. R., Thoene, M. A., Sablin, E. P., & Polosukhina, K. (2001) · Biophysical Chemistry · doi:10.1016/s0301-4622(01)00197-1 · Cited by 5
L’interaction stathmine–tubuline et la régulation de la dynamique des microtubules
Gigant, B., Martin-Barbey, C., Curmi, P. A., Sobel, A., & Knossow, M. (2003) · Pathologie Biologie · doi:10.1016/s0369-8114(02)00324-3 · Cited by 5
Mitotic Spindle Assembly Mechanisms
Heald, R., & Walczak, C. (2008) · Springer eBooks · doi:10.1007/978-0-387-69076-6_8 · Cited by 5
Cilia and Related Microtubular Arrays in the Eukaryotic Cell
Satir, P. (1997) · Comprehensive physiology · doi:10.1002/cphy.cp140120 · Cited by 5
Physical Modeling of microtubule force generation and self-organization
Tanase, C. (2004) · doi:10.18174/121582 · Cited by 5
Biophysical limits of ultrafast cellular motilityPreprint
Chang, R., & Prakash, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.22.609204 · Cited by 5
Cytoskeleton Dynamics and Binding Factors
Grintsevich, E. E., & Reisler, E. (2012) · Neuromethods · doi:10.1007/978-1-62703-266-7_4 · Cited by 4
Modeling microtubule dynamic instability: Microtubule growth, shortening and pause
Darko, F. L. A., & White, D. (2022) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2022.111257 · Cited by 4
de Forges, H., Pilon, A., Poüs, C., & Perez, F. (2013) · Methods in cell biology · doi:10.1016/b978-0-12-407757-7.00010-4 · Cited by 4
A microtubule dynamics reconstitutional convention
Slep, K. C. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201610066 · Cited by 4
Cario, A., Wickramasinghe, S. P., Rhoades, E. R., & Berger, C. L. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102526 · Cited by 4
Modeling of sensing potency of cytoskeletal systems decorated with metabolic enzymes
Oláh, J., Norris, V., & Ovádi, J. (2014) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2014.10.018 · Cited by 4
Self-Organized Criticality and Dynamic Instability of Microtubule Growth
Babinec, P., & Babincová, M. (1995) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1995-9-1024 · Cited by 4
Honey, P. (2002) · Training Strategies for Tomorrow · doi:10.1108/13697230210815926 · Cited by 4
Kinesin-propelled label-free microtubules imaged with interference reflection microscopy
Saper, G., & Hess, H. (2020) · New Journal of Physics · doi:10.1088/1367-2630/abb47b · Cited by 4
Gliksman, N. R., Parsons, S. F., & Salmon, E. D. (1993) · Methods in cell biology · doi:10.1016/s0091-679x(08)60174-0 · Cited by 4
Self-citationDynamic Nanodevices Based on Protein Molecular Motors
Nicolau, D. V. (2007) · Springer eBooks · doi:10.1007/978-0-387-25842-3_12 · Cited by 4
Traces of brain microtubule-associated proteins affect dynamic properties of microtubules
Keates, R. A. B. (1990) · Biochemistry and Cell Biology · doi:10.1139/o90-178 · Cited by 4
Structural plugs at microtubule ends may regulate polymer dynamics in vitro
Azhar, S., & Murphy, D. B. (1990) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970150304 · Cited by 4
A cryo-ET study of microtubules in axonsPreprint
Foster, H. E., Ventura Santos, C., & Carter, A. P. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.29.437471 · Cited by 4
Microtubule dynamic instability is sensitive to specific biological viscogens in vitroPreprint
Molines, A. T., Edrington, C. H., Tetlalmatzi, S. C., Chang, F., & Brouhard, G. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.27.596091 · Cited by 4
A Depolymerization Ratchet for Intracellular Transport
Peskin, C. S., Lombillo, V. A., & OSTER, G. F. (1996) · Institute for Nonlinear Science · doi:10.1007/978-1-4612-3992-5_20 · Cited by 4
Cellular Olympics: Ultrafast Cellular Motility Across the Tree of Life
Chang, R., & Prakash, M. (2025) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041020-021038 · Cited by 3
Computer simulation reveals the effect of severing enzymes on dynamic and stabilized microtubules
Sen, A., & Kunwar, A. (2023) · Physical Biology · doi:10.1088/1478-3975/acc301 · Cited by 3
Emergent microtubule properties in a model of filament turnover and nucleation
Nelson, A. C., McKinley, S. A., Rolls, M. M., & Ciocanel, M.-V. (2025) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2025.112254 · Cited by 3
Biophysical Properties of Stable Microtubules in Neurites Revealed by Optical Techniques.
Kurachi, M., Komiya, Y., & Tashiro, T. (1999) · Cell Structure and Function · doi:10.1247/csf.24.405 · Cited by 3
Hossain, M. S., King, S. V., & Preza, C. (2015) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2077322 · Cited by 3
Niu, X., Zheng, F., & Fu, C. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz039 · Cited by 3
Inhibition of polo-like kinase 1 suppresses microtubule dynamics in MCF-7 cells
Rashid, A., Naaz, A., Rai, A., Chatterji, B. P., & Panda, D. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03664-y · Cited by 3
Reliable and robust control of nucleus centering is contingent on nonequilibrium force patterns
Jain, I., Rao, M., & Tran, P. T. (2023) · iScience · doi:10.1016/j.isci.2023.106665 · Cited by 2
Regulation of the microtubule network; the shaft matters!
Mehidi, A., & Aumeier, C. (2023) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2023.100457 · Cited by 4
BubR1 depletion delays apoptosis in the microtubule-depolymerized cells
Naaz, A., Ahad, S., Rai, A., Surolia, A., & Panda, D. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.11.015 · Cited by 3
A celebration of the 25th anniversary of chromatin-mediated spindle assembly
Verma, V., & Maresca, T. J. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e21-08-0400 · Cited by 3
Chapter 20 Automated Spatial Mapping of Microtubule Catastrophe Rates in Fission Yeast
Tischer, C., Brunner, D., & Dogterom, M. (2008) · Methods in cell biology · doi:10.1016/s0091-679x(08)00620-1 · Cited by 3
Molecular responses of human dermal fibroblasts to dual cues: Contact guidance and mechanical load
Mudera, V., Pleass, R., Eastwood, M., Tarnuzzer, R. W., Schultz, G., Khaw, P. T., McGrouther, D. A., & Brown, R. A. (2000) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(200001)45:1 · Cited by 135
Hui, T. H., Zheng, F., Lin, Y., & Fu, C. (2016) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2016.02.017 · Cited by 3
Amos, L., & Amos, W. B. (1991) · doi:10.1007/978-1-349-21739-7_7 · Cited by 3
Feizabadi, M. S., Rosario, B., & Hernandez, M. A. V. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.012 · Cited by 3
Phytochemicals as Anticancer Drugs: Targeting the Microtubular Network of Cancer Cells
Khan, R., Chatterjee, A., Ghosh, H., Kapoor, S., & Ray, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-6920-9_3 · Cited by 3
Molecular Motors Enhance Microtubule Lattice Plasticity
Lecompte, W., & John, K. (2023) · PRX Life · doi:10.1103/prxlife.1.013012 · Cited by 4
Stabilization of microtubules by dynein-binding in vitro. Stability of microtubule-dynein complex
Ohba, S., Kamata, K., & Miki‐Noumura, T. (1993) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(93)90031-3 · Cited by 3
Chapter 8 In Vitro Assays for Studying Saccharomyces cerevisiae Kinetochore Activity
Severin, F. F., Kaplan, K. B., Sorger, P. K., & Hyman, A. A. (1998) · Methods in cell biology · doi:10.1016/s0091-679x(08)61979-2 · Cited by 3
WOLF, K. W. (1994) · Zygote · doi:10.1017/s0967199400001805 · Cited by 3
CENP-F couples cargo to growing and shortening microtubule endsPreprint
Kanfer, G., Peterka, M., Arzhanik, V. K., Drobyshev, A. L., Ataullakhanov, F. I., Volkov, V. A., & Kornmann, B. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/083618 · Cited by 3
Two-step interphase microtubule disassembly aids spindle morphogenesisPreprint
Mchedlishvili, N., Matthews, H. K., Corrigan, A. M., & Baum, B. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/126342 · Cited by 3
Metadata
- Authors
- Walker, R. A., O'Brien, E. T., Pryer, N. K., Soboeiro, M. F., Voter, W. A., Erickson, H. P., & Salmon, E. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Department of Biology, University of North Carolina, Chapel Hill 27599-3280.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1988-10-01
- Volume
- 107
- Issue
- 4
- Pages
- 1437-1448
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC2115242
- OpenAlex
- W2015005644
- Cited by
- 980
- References
- 45
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 19 · 2023: 22 · 2022: 37 · 2021: 27 · 2020: 27 · 2019: 43 · 2018: 35 · 2017: 30 · 2016: 36 · 2015: 34 · 2014: 31 · 2013: 23 · 2012: 23
- FWCI
- 10.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM24364, GM 28553)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- microtubule dynamic instability, GTP cap, treadmilling
- MeSH terms
- Animals, Guanosine Triphosphate, Kinetics, Microtubules, Protein Binding, Swine, Tubulin, Video Recording, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
