The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis.
Open accessAbstract
Despite extensive efforts, little progress has been made in identifying the factors that induce hepatic fibrosis. Transforming growth factor-beta (TGF-beta) has been shown to enhance collagen production, therefore its role in hepatic fibrosis was investigated. Treatment of cultured hepatic cells with TGF-beta 1 increased type I procollagen mRNA levels 13-fold due to post-transcriptional gene regulation. When two animal models of hepatic fibrosis, murine schistosomiasis and CCl4-treated rats, were examined, they both exhibited increased levels of TGF-beta 1 gene expression at times that somewhat preceded the increase in collagen synthesis. In contrast, in murine schistosomiasis, mRNA levels of tumor necrosis factor and interleukin-1 peaked early in the fibrogenic process. Immunohistochemical analysis showed TGF-beta 1 to be present in normal mouse liver and to be markedly increased in mice infected with schistosomiasis. TGF-beta 1 appeared in the hepatic parenchyma, primarily in hepatocytes. These findings strongly suggest a role for TGF-beta 1 in a pathophysiological state.
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Cites
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
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Hepatic toxicity resulting from cancer treatment
Lawrence, T. S., Robertson, J. M., Anscher, M. S., Jirtle, R. L., Ensminger, W. D., & Fajardo, L. F. (1995) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(94)00418-k · Cited by 721
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Metadata
- Authors
- Czaja, M. J., Weiner, F. R., Flanders, K. C., Giambrone, M. A., Wind, R., Biempica, L., & Zern, M. A.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1989-06-01
- Volume
- 108
- Issue
- 6
- Pages
- 2477-2482
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2151376215
- Cited by
- 415
- References
- 2
- FWCI
- 13.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Czaja, M. J., Weiner, F. R., Flanders, K. C., Giambrone, M. A., Wind, R., Biempica, L., & Zern, M. A. (1989). In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis. The Journal of cell biology. https://doi.org/10.1083/jcb.108.6.2477
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