The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Multifunctional Ca2+/calmodulin-dependent protein kinase is necessary for nuclear envelope breakdown.
Open accessAbstract
The role of multifunctional Ca2+/calmodulin-dependent protein kinase (CaM kinase) in nuclear envelope breakdown (NEB) was investigated in sea urchin eggs. The eggs contain a 56-kD polypeptide which appears to be a homologue of neuronal CaM kinase. For example, it undergoes Ca2+/calmodulin-dependent autophosphorylation that converts it to a Ca2(+)-independent species, a hallmark of multifunctional CaM kinase. It is homologous to the alpha subunit of rat brain CaM kinase. Autophosphorylation and substrate phosphorylation by the sea urchin egg kinase are inhibited in vitro by CaMK(273-302), a synthetic peptide corresponding to the autoinhibitory domain of the neuronal CaM kinase. This peptide inhibited NEB when microinjected into sea urchin eggs. Only one mAb to the neuronal enzyme immunoprecipitated the 56-kD polypeptide. Only this antibody blocked or significantly delayed NEB when microinjected into sea urchin eggs. These results suggest that sea urchin eggs contain multifunctional CaM kinase, and that this enzyme is involved in the control of NEB during mitotic division.
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Cites
Miller, S. (1986) · Cell · doi:10.1016/0092-8674(86)90008-5 · Cited by 864
Kelly, P. T., Weinberger, R. P., & Waxham, M. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.4991 · Cited by 91
Cited by
Sensitivity of CaM Kinase II to the Frequency of Ca 2+ Oscillations
De Koninck, P., & Schulman, H. (1998) · Science · doi:10.1126/science.279.5348.227 · Cited by 1,269
Self-citationCalcium at Fertilization and in Early Development
Whitaker, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2005 · Cited by 512
Leonard, A. S., Lim, I. A., Hemsworth, D. E., Horne, M. C., & Hell, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3239 · Cited by 385
Pettit, D. L., Perlman, S., & Malinow, R. (1994) · Science · doi:10.1126/science.7997883 · Cited by 329
Francisco, L., Wang, W., & Chan, C. S. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4731 · Cited by 266
Metadata
- Authors
- Baitinger, C., Alderton, J., Poenie, M., Schulman, H., & Steinhardt, R. A.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1990-11-01
- Volume
- 111
- Issue
- 5
- Pages
- 1763-1773
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2132161866
- Cited by
- 169
- References
- 2
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Baitinger, C., Alderton, J., Poenie, M., Schulman, H., & Steinhardt, R. A. (1990). Multifunctional Ca2+/calmodulin-dependent protein kinase is necessary for nuclear envelope breakdown. The Journal of cell biology. https://doi.org/10.1083/jcb.111.5.1763
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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