The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13)
Open accessAbstract
We have recently described a novel cDNA, SR13 (Welcher, A. A., U. Suter, M. De Leon, G. J. Snipes, and E. M. Shooter. 1991. Proc. Natl. Acad. Sci. USA. 88:7195-7199), that is repressed after sciatic nerve crush injury and shows homology to both the growth arrest-specific mRNA, gas3 (Manfioletti, G., M. E. Ruaro, G. Del Sal, L. Philipson, and C. Schneider, 1990. Mol. Cell Biol. 10:2924-2930), and to the myelin protein, PASII (Kitamura, K., M. Suzuki, and K. Uyemura. 1976. Biochim. Biophys. Acta. 455:806-816). In this report, we show that the 22-kD SR13 protein is expressed in the compact portion of essentially all myelinated fibers in the peripheral nervous system. Although SR13 mRNA was found in the central nervous system, no corresponding SR13 protein could be detected by either immunoblot analysis or by immunohistochemistry. Northern and immunoblot analysis of SR13 mRNA and protein expression during development of the peripheral nervous system reveal a pattern similar to other myelin proteins. Furthermore, we demonstrate by in situ mRNA hybridization on tissue sections and on individual nerve fibers that SR13 mRNA is produced predominantly by Schwann cells. We conclude that the SR13 protein is apparently exclusively expressed in the peripheral nervous system where it is a major component of myelin. Thus, we propose the name Peripheral Myelin Protein-22 (PMP-22) for the proteins and cDNA previously designated PASII, SR13, and gas3.
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Cites
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Cited by
Influence of aging on peripheral nerve function and regeneration
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N-myc Downstream-Regulated Gene 1 Is Mutated in Hereditary Motor and Sensory Neuropathy–Lom
Kalaydjieva, L., Gresham, D., Gooding, R., Heather, L., Baas, F., de Jonge, R., Blechschmidt, K., Angelicheva, D., Chandler, D., Worsley, P., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/302978 · Cited by 353
Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration
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Neuroactive steroids and peripheral myelin proteins
Magnaghi, V., Cavarretta, I., Galbiati, M., Martini, L., & Melcangi, R. C. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00140-0 · Cited by 116
Metadata
- Authors
- Snipes, G., Suter, U., Welcher, A., & Shooter, E.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1992-04-01
- Volume
- 117
- Issue
- 1
- Pages
- 225-238
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2140926801
- Cited by
- 422
- References
- 40
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Snipes, G., Suter, U., Welcher, A., & Shooter, E. (1992). Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13). The Journal of cell biology. https://doi.org/10.1083/jcb.117.1.225
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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