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Lattice defects in microtubules: protofilament numbers vary within individual microtubules
Open accessAbstract
We have used cryo-electron microscopy of vitrified specimens to study microtubules assembled both from three cycle purified tubulin (3x-tubulin) and in cell free extracts of Xenopus eggs. In vitro assembled 3x-tubulin samples have a majority of microtubules with 14 protofilaments whereas in cell extracts most microtubules have 13 protofilaments. Microtubule polymorphism was observed in both cases. The number of protofilaments can change abruptly along individual microtubules usually by single increments but double increments also occur. For 3x-tubulin, increasing the magnesium concentration decreases the proportion of 14 protofilament microtubules and decreases the average separation between transitions in these microtubules. Protofilament discontinuities may correspond to dislocation-like defects in the microtubule surface lattice.
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Citations
Cites
Evidence for a mixed lattice in microtubules reassembled in vitro
McEwen, B., & Edelstein, S. J. (1980) · Journal of Molecular Biology · doi:10.1016/0022-2836(80)90300-9 · Cited by 77
Cited by
Causes and Consequences of Microtubule Acetylation
Janke, C., & Montagnac, G. (2017) · Current Biology · doi:10.1016/j.cub.2017.10.044 · Cited by 312
Microtubules self-repair in response to mechanical stress
Schaedel, L., John, K., Gaillard, J., Nachury, M. V., Blanchoin, L., & Théry, M. (2015) · Nature Materials · doi:10.1038/nmat4396 · Cited by 294
Hamel, E. (2003) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:38:1:1 · Cited by 272
Hyman, A. A., Chrétien, D., Arnal, I., & Wade, R. H. (1995) · The Journal of cell biology · doi:10.1083/jcb.128.1.117 · Cited by 240
Self-citationKellogg, E. H., Hejab, N. M. A., Howes, S., Northcote, P., Miller, J. H., Díaz, J. F., Downing, K. H., & Nogales, E. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.01.001 · Cited by 234
Metadata
- Authors
- Chrétien, D., Metoz, F., Verde, F., Karsenti, E., & Wade, R.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1992-06-01
- Volume
- 117
- Issue
- 5
- Pages
- 1031-1040
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2159335259
- Cited by
- 248
- References
- 1
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chrétien, D., Metoz, F., Verde, F., Karsenti, E., & Wade, R. (1992). Lattice defects in microtubules: protofilament numbers vary within individual microtubules. The Journal of cell biology. https://doi.org/10.1083/jcb.117.5.1031
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
