The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Enteric defensins: antibiotic peptide components of intestinal host defense.
Open accessAbstract
Five intestinal defensins, termed cryptdins 1-5, have been purified from mouse small bowel, sequenced, and localized to the epithelium by immunohistochemistry. Although identified as members of the defensin peptide family by peptide sequencing, enteric defensins are novel in that four cryptdins have amino termini which are three to six residues longer than those of leukocyte-derived defensins. A fifth cryptdin is the first defensin to diverge from the previously invariant spacing of cysteines in the peptide structure. The most abundant enteric defensin, cryptdin-1, had antimicrobial activity against an attenuated phoP mutant of Salmonella typhimurium but was not active against the virulent wild-type parent. Immunohistochemical localization demonstrated that cryptdin-1, and probably cryptdins 2 and 3, occur exclusively in Paneth cells, where the peptides appear to be associated with cytoplasmic granules. Biochemical and immunologic analysis of the luminal contents of the small intestine suggest that cryptdin peptides are secreted into the lumen, similar to Paneth cell secretion of lysozyme. The presence of several enteric defensins in the intestinal epithelium, evidence of their presence in the lumen, and the antibacterial activity of cryptdin-1 suggest that these peptides contribute to the antimicrobial barrier function of the small bowel mucosa.
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Cites
Defensins. Natural peptide antibiotics of human neutrophils.
Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S., Daher, K., Bainton, D. F., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112120 · Cited by 1,416
Self-citationA two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.
Miller, S. I., Kukral, A. M., & Mekalanos, J. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.5054 · Cited by 929
Self-citationInteraction of human defensins with Escherichia coli. Mechanism of bactericidal activity.
Lehrer, R. I., Barton, A., Daher, K. A., Harwig, S. S., Ganz, T., & Selsted, M. E. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114198 · Cited by 715
Self-citationUltrasensitive assays for endogenous antimicrobial polypeptides
Lehrer, R. I., Rosenman, M., Harwig, S. S. S. L., Jackson, R., & Eisenhauer, P. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90021-7 · Cited by 671
A Salmonella Locus that Controls Resistance to Microbicidal Proteins from Phagocytic Cells
Fields, P. I., Groisman, E. A., & Heffron, F. (1989) · Science · doi:10.1126/science.2646710 · Cited by 540
Kagan, B. L., Selsted, M. E., Ganz, T., & Lehrer, R. I. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.210 · Cited by 532
Self-citationCHEMICAL SYNTHESIS OF PEPTIDES AND PROTEINS
Kent, S. B. H. (1988) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.57.070188.004521 · Cited by 518
Crystal Structure of Defensin HNP-3, an Amphiphilic Dimer: Mechanisms of Membrane Permeabilization
Hill, C. P., Yee, J., Selsted, M. E., & Eisenberg, D. (1991) · Science · doi:10.1126/science.2006422 · Cited by 507
Self-citationDefensins: Endogenous antibiotic peptides of animal cells
Lehrer, R. I., Ganz, T., & Selsted, M. E. (1991) · Cell · doi:10.1016/0092-8674(91)90632-9 · Cited by 348
Self-citationBjerknes, M., & Cheng, H. (1981) · American Journal of Anatomy · doi:10.1002/aja.1001600105 · Cited by 264
Cited by
Frohm, M., Agerberth, B., Ahangari, G., Ståhle-Bäckdahl, M., Lidén, S., Wigzell, H., & Gudmundsson, G. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15258 · Cited by 803
Antimicrobial Peptides from Plants
Broekaert, W. F., Cammue, B. P. A., De Bolle, M. F. C., Thevissen, K., De Samblanx, G. W., Osborn, R. W., & Nielson, K. (1997) · Critical Reviews in Plant Sciences · doi:10.1080/07352689709701952 · Cited by 678
Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414
Mallow, E. B., Harris, A., Salzman, N., Russell, J. P., DeBerardinis, R. J., Ruchelli, E., & Bevins, C. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4038 · Cited by 296
Andersson, M., Gunne, H., Agerberth, B., Boman, A., Bergman, T., Sillard, R., Jörnvall, H., Mutt, V., Olsson, B., & Wigzell, H. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07150.x · Cited by 283
Metadata
- Authors
- Selsted, M. E., Miller, S. I., Henschen, A. H., & Ouellette, A. J.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1992-08-15
- Volume
- 118
- Issue
- 4
- Pages
- 929-936
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2076916880
- Cited by
- 309
- References
- 28
- FWCI
- 13.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Selsted, M. E., Miller, S. I., Henschen, A. H., & Ouellette, A. J. (1992). Enteric defensins: antibiotic peptide components of intestinal host defense. The Journal of cell biology. https://doi.org/10.1083/jcb.118.4.929
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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