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Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae
Open accessAbstract
Potocytosis is an endocytic pathway that utilizes glycosylphosphatidylinositol-anchored membrane proteins and caveolae to concentrate and internalize small molecules. We now report that activators of protein kinase C are potent inhibitors of potocytosis. Activators such as phorbol-12-myristate-13-acetate (PMA) inhibit the internalization of receptors for 5-methyltetrahydrofolate but allow the internal receptor pool to return to the cell surface. PMA does not affect the clustering of the folate receptor but instead markedly reduces the number of caveolae. Exposure to PMA totally blocks the intracellular accumulation of 5-methyltetrahydrofolate without affecting receptor-independent uptake or the formation of polyglutamylated species of 5-methyltetrahydrofolate in the cytoplasm. These data suggest that PMA inhibits uptake by inactivating caveolae internalization.
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Citations
Cited by
Dynamin-mediated Internalization of Caveolae
Henley, J. R., Krueger, E. W. A., Oswald, B. J., & McNiven, M. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.1.85 · Cited by 767
Compartmentalized Production of Ceramide at the Cell Surface
Liu, P., & Anderson, R. G. W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27179 · Cited by 344
Self-citationRemacle, A., Murphy, G., & Roghi, C. (2003) · Journal of Cell Science · doi:10.1242/jcs.00710 · Cited by 264
Caveolin-1, cellular senescence and age-related diseases
Zou, H., Stoppani, E., Volonte, D., & Galbiati, F. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.11.001 · Cited by 112
Metadata
- Authors
- Smart, E., Foster, D., Ying, Y., Kamen, B., & Anderson, R.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1994-02-01
- Volume
- 124
- Issue
- 3
- Pages
- 307-313
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2095787018
- Cited by
- 181
- References
- 0
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae. https://app.cochat.ai/papers/10.1083/jcb.124.3.307
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- Smart, E., Foster, D., Ying, Y., Kamen, B., & Anderson, R. (1994). Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolae. The Journal of cell biology. https://doi.org/10.1083/jcb.124.3.307
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