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Cited by 347

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members.

Open access
Takeuchi, K, Sato, N, Kasahara, H, Funayama, N, Nagafuchi, A, Yonemura, S, Tsukita, S, Tsukita, S·1994·The Journal of cell biology
DOI 10.1083/jcb.125.6.1371
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Abstract

To examine the functions of ERM family members (ezrin, radixin, and moesin), mouse epithelial cells (MTD-1A cells) and thymoma cells (L5178Y), which coexpress all of them, were cultured in the presence of antisense phosphorothioate oligonucleotides (PONs) complementary to ERM sequences. Immunoblotting revealed that the antisense PONs selectively suppressed the expression of each member. Immunofluorescence microscopy of these ezrin, radixin, or moesin "single-suppressed" MTD-1A cells revealed that the ERM family members are colocalized at cell-cell adhesion sites, microvilli, and cleavage furrows, where actin filaments are densely associated with plasma membranes. The ezrin/radixin/moesin antisense PONs mixture induced the destruction of both cell-cell and cell-substrate adhesion, as well as the disappearance of microvilli. Ezrin or radixin antisense PONs individually affected the initial step of the formation of both cell-cell and cell-substrate adhesion, but did not affect the microvilli structures. In sharp contrast, moesin antisense PONs did not singly affect cell-cell and cell-substrate adhesion, whereas it partly affected the microvilli structures. These data indicate that ezrin and radixin can be functionally substituted, that moesin has some synergetic functional interaction with ezrin and radixin, and that these ERM family members are involved in cell-cell and cell-substrate adhesion, as well as microvilli formation.

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Metadata

Authors
Takeuchi, K., Sato, N., Kasahara, H., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S.
Venue
The Journal of cell biology
Publisher
Rockefeller University Press
Published
1994-06-15
Volume
125
Issue
6
Pages
1371-1384
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.125.6.1371
OpenAlex
W1991030946
Cited by
347
References
32
FWCI
8.44
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. https://app.cochat.ai/papers/10.1083/jcb.125.6.1371
The paper
Takeuchi, K., Sato, N., Kasahara, H., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1994). Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. The Journal of cell biology. https://doi.org/10.1083/jcb.125.6.1371

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.