The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Early events in DNA replication require cyclin E and are blocked by p21CIP1.
Open accessAbstract
Using immunodepletion of cyclin E and the inhibitor protein p21WAF/CIP1, we demonstrate that the cyclin E protein, in association with Cdk2, is required for the elongation phase of replication on single-stranded substrates. Although cyclin E/Cdk2 is likely to be the major target by which p21 inhibits the initiation of sperm DNA replication, p21 can inhibit single-stranded replication through a mechanism dependent on PCNA. While the cyclin E/Cdk2 complex appears to have a role in the initiation of DNA replication, another Cdk kinase, possibly cyclin A/Cdk, may be involved in a later step controlling the switch from initiation to elongation. The provision of a large maternal pool of cyclin E protein shows that regulators of replication are constitutively present, which explains the lack of a protein synthesis requirement for replication in the early embryonic cell cycle.
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Citations
Cites
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/369574a0 · Cited by 1,655
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA
Chen, J., Jackson, P. K., Kirschner, M. W., & Dutta, A. (1995) · Nature · doi:10.1038/374386a0 · Cited by 548 · cited 11×
“Recent studies have also seen that p21 can block sperm replication (Strausfeld et al., 1994; Adachi and Laemmli, 1994; Yan and Newport, 1995) and that this inhibition is mediated by the NH2-terminal cyclin/Cdk2 binding domain of p21, which binds to cyclin/Cdk2 (Chen et al., 1995).”
BackgroundInfluentialSelf-citation
Cited by
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Cyclin-Binding Motifs Are Essential for the Function of p21 CIP1
Chen, J., Saha, P., Kornbluth, S., Dynlacht, B. D., & Dutta, A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4673 · Cited by 320
Metadata
- Authors
- Jackson, P. K., Chevalier, S., Philippe, M., & Kirschner, M. W.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1995-08-15
- Volume
- 130
- Issue
- 4
- Pages
- 755-769
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2006046129
- Cited by
- 200
- References
- 2
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Jackson, P. K., Chevalier, S., Philippe, M., & Kirschner, M. W. (1995). Early events in DNA replication require cyclin E and are blocked by p21CIP1. The Journal of cell biology. https://doi.org/10.1083/jcb.130.4.755
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
