The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus.
Open accessAbstract
We determined the folding of chromosomes in interphase nuclei by measuring the distance between points on the same chromosome. Over 25,000 measurements were made in G0/G1 nuclei between DNA sequences separated by 0.15-190 megabase pairs (Mbp) on three human chromosomes. The DNA sequences were specifically labeled by fluorescence in situ hybridization. The relationship between mean-square interphase distance and genomic separation has two linear phases, with a transition at approximately 2 Mbp. This biphasic relationship indicates the existence of two organizational levels at scales > 100 kbp. On one level, chromatin appears to be arranged in large loops several Mbp in size. Within each loop, chromatin is randomly folded. On the second level, specific loop-attachment sites are arranged to form a supple, backbonelike structure, which also shows characteristic random walk behavior. This random walk/giant loop model is the simplest model that fully describes the observed large-scale spatial relationships. Additional evidence for large loops comes from measurements among probes in Xq28, where interphase distance increases and then locally decreases with increasing genomic separation.
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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
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Bickmore, W. A., & van Steensel, B. (2013) · Cell · doi:10.1016/j.cell.2013.02.001 · Cited by 725
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Cremer, T., Cremer, M., Dietzel, S., Müller, S., Solovei, I., & Fakan, S. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.04.007 · Cited by 599
Metadata
- Authors
- Yokota, H., van den Engh, G., Hearst, J. E., Sachs, R. K., & Trask, B. J.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1995-09-15
- Volume
- 130
- Issue
- 6
- Pages
- 1239-1249
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2169941328
- Cited by
- 285
- References
- 39
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Yokota, H., van den Engh, G., Hearst, J. E., Sachs, R. K., & Trask, B. J. (1995). Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus. The Journal of cell biology. https://doi.org/10.1083/jcb.130.6.1239
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
