The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Nuclear Localization of Cyclin B1 Controls Mitotic Entry After DNA Damage
Open accessAbstract
Mitosis in human cells is initiated by the protein kinase Cdc2-cyclin B1, which is activated at the end of G2 by dephosphorylation of two inhibitory residues, Thr14 and Tyr15. The G2 arrest that occurs after DNA damage is due in part to stabilization of phosphorylation at these sites. We explored the possibility that entry into mitosis is also regulated by the subcellular location of Cdc2-cyclin B1, which is suddenly imported into the nucleus at the end of G2. We measured the timing of mitosis in HeLa cells expressing a constitutively nuclear cyclin B1 mutant. Parallel studies were performed with cells expressing Cdc2AF, a Cdc2 mutant that cannot be phosphorylated at inhibitory sites. Whereas nuclear cyclin B1 and Cdc2AF each had little effect under normal growth conditions, together they induced a striking premature mitotic phenotype. Nuclear targeting of cyclin B1 was particularly effective in cells arrested in G2 by DNA damage, where it greatly reduced the damage-induced G2 arrest. Expression of nuclear cyclin B1 and Cdc2AF also resulted in significant defects in the exit from mitosis. Thus, nuclear targeting of cyclin B1 and dephosphorylation of Cdc2 both contribute to the control of mitotic entry and exit in human cells.
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Cited by
Cell death by mitotic catastrophe: a molecular definition
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14-3-3σ is required to prevent mitotic catastrophe after DNA damage
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The Ki-67 Protein: Fascinating Forms and an Unknown Function
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Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase
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Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe
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Metadata
- Authors
- Jin, P., Hardy, S., & Morgan, D. O.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1998-05-18
- Volume
- 141
- Issue
- 4
- Pages
- 875-885
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1901442544
- Cited by
- 298
- References
- 52
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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