The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein
Open accessAbstract
We have isolated a novel actin filament–binding protein, named afadin, localized at cadherin-based cell–cell adherens junctions (AJs) in various tissues and cell lines. Afadin has one PDZ domain, three proline-rich regions, and one actin filament–binding domain. We found here that afadin directly interacted with a family of the immunoglobulin superfamily, which was isolated originally as the poliovirus receptor–related protein (PRR) family consisting of PRR1 and -2, and has been identified recently to be the alphaherpes virus receptor. PRR has a COOH-terminal consensus motif to which the PDZ domain of afadin binds. PRR and afadin were colocalized at cadherin-based cell–cell AJs in various tissues and cell lines. In E-cadherin–expressing EL cells, PRR was recruited to cadherin-based cell–cell AJs through interaction with afadin. PRR showed Ca2+-independent cell–cell adhesion activity. These results indicate that PRR is a cell–cell adhesion molecule of the immunoglobulin superfamily which is recruited to cadherin-based cell–cell AJs through interaction with afadin. We rename PRR as nectin (taken from the Latin word “necto” meaning “to connect”).
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., & Cantley, L. C. (1997) · Science · doi:10.1126/science.275.5296.73 · Cited by 1,385
Gumbiner, B., Stevenson, B., & Grimaldi, A. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1575 · Cited by 799
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Cited by
González-Mariscal, L., Betanzos, A., Nava, P., & Jaramillo, B. E. (2003) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(02)00037-8 · Cited by 1,160
Regulation of Cadherin Adhesive Activity
Gumbiner, B. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.3.399 · Cited by 787
Perez-Moreno, M., Jamora, C., & Fuchs, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00108-9 · Cited by 721
Adherens Junction: Molecular Architecture and Regulation
Meng, W., & Takeichi, M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002899 · Cited by 593
Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation
Takai, Y., Miyoshi, J., Ikeda, W., & Ogita, H. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2457 · Cited by 586
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Metadata
- Authors
- Takahashi, K., Nakanishi, H., Miyahara, M., Mandai, K., Satoh, K., Satoh, A., Nishioka, H., Aoki, J., Nomoto, A., Mizoguchi, A., & Takai, Y.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1999-05-03
- Volume
- 145
- Issue
- 3
- Pages
- 539-549
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2126750826
- Cited by
- 539
- References
- 4
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein. https://app.cochat.ai/papers/10.1083/jcb.145.3.539
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- Takahashi, K., Nakanishi, H., Miyahara, M., Mandai, K., Satoh, K., Satoh, A., Nishioka, H., Aoki, J., Nomoto, A., Mizoguchi, A., & Takai, Y. (1999). Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein. The Journal of Cell Biology. https://doi.org/10.1083/jcb.145.3.539
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