The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells
Open accessAbstract
The mechanism of action of the oncogene bcl-2, a key regulator of the apoptotic process, is still debated. We have employed organelle-targeted chimeras of the Ca2+-sensitive photoprotein, aequorin, to investigate in detail the effect of Bcl-2 overexpression on intracellular Ca2+ homeostasis. In the ER and the Golgi apparatus, Bcl-2 overexpression increases the Ca2+ leak (while leaving Ca2+ accumulation unaffected), hence reducing the steady-state [Ca2+] levels. As a direct consequence, the [Ca2+] increases caused by inositol 1,4,5 trisphosphate (IP3)-generating agonists were reduced in amplitude in both the cytosol and the mitochondria. Bcl-2 overexpression also reduced the rate of Ca2+ influx activated by Ca2+ store depletion, possibly by an adaptive downregulation of this pathway. By interfering with Ca2+-dependent events at multiple intracellular sites, these effects of Bcl-2 on intracellular Ca2+ homeostasis may contribute to the protective role of this oncogene against programed cell death.
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Pinton, P., Pozzan, T., & Rizzuto, R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5298 · Cited by 435 · cited 2×
“In addition, since we recently have demonstrated that the Golgi apparatus shares many of the Ca 2 1 homeostatic properties of the ER (Pinton et al., 1998), this latter organelle was also investigated.”
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Metadata
- Authors
- Pinton, P., Ferrari, D., Magalhães, P., Schulze-Osthoff, K., Di Virgilio, F., Pozzan, T., & Rizzuto, R.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2000-03-06
- Volume
- 148
- Issue
- 5
- Pages
- 857-862
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2141000153
- Cited by
- 471
- References
- 1
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells. https://app.cochat.ai/papers/10.1083/jcb.148.5.857
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- Pinton, P., Ferrari, D., Magalhães, P., Schulze-Osthoff, K., Di Virgilio, F., Pozzan, T., & Rizzuto, R. (2000). Reduced Loading of Intracellular Ca2+ Stores and Downregulation of Capacitative Ca2+Influx in Bcl-2–Overexpressing Cells. The Journal of Cell Biology. https://doi.org/10.1083/jcb.148.5.857
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