The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Protein Particles in Chlamydomonas Flagella Undergo a Transport Cycle Consisting of Four Phases
Open accessAbstract
We used an improved procedure to analyze the intraflagellar transport (IFT) of protein particles in Chlamydomonas and found that the frequency of the particles, not only the velocity, changes at each end of the flagella. Thus, particles undergo structural remodeling at both flagellar locations. Therefore, we propose that the IFT consists of a cycle composed of at least four phases: phases II and IV, in which particles undergo anterograde and retrograde transport, respectively, and phases I and III, in which particles are remodeled/exchanged at the proximal and distal end of the flagellum, respectively. In support of our model, we also identified 13 distinct mutants of flagellar assembly (fla), each defective in one or two consecutive phases of the IFT cycle. The phase I-II mutant fla10-1 revealed that cytoplasmic dynein requires the function of kinesin II to participate in the cycle. Phase I and II mutants accumulate complex A, a particle component, near the basal bodies. In contrast, phase III and IV mutants accumulate complex B, a second particle component, in flagellar bulges. Thus, fla mutations affect the function of each complex at different phases of the cycle.
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Cites
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The DHC1b (DHC2) Isoform of Cytoplasmic Dynein Is Required for Flagellar Assembly
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Cytoplasmic Dynein Heavy Chain 1b Is Required for Flagellar Assembly in Chlamydomonas
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Cited by
The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982
The primary cilium: a signalling centre during vertebrate development
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Rosenbaum, J. L., & Witman, G. B. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm952 · Cited by 1,423
Ciliogenesis: building the cell's antenna
Ishikawa, H., & Marshall, W. F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3085 · Cited by 961
Chapter Two Intraflagellar Transport (IFT)
Pedersen, L. B., & Rosenbaum, J. L. (2008) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)00802-8 · Cited by 521
Metadata
- Authors
- Iomini, C., Babaev-Khaimov, V., Sassaroli, M., & Piperno, G.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2001-03-26
- Volume
- 153
- Issue
- 1
- Pages
- 13-24
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1993880917
- Cited by
- 241
- References
- 7
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Iomini, C., Babaev-Khaimov, V., Sassaroli, M., & Piperno, G. (2001). Protein Particles in Chlamydomonas Flagella Undergo a Transport Cycle Consisting of Four Phases. The Journal of Cell Biology. https://doi.org/10.1083/jcb.153.1.13
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
