The DOI matches its Crossref record.
Interactions and regulation of molecular motors in Xenopus melanophores
Open accessAbstract
Many cellular components are transported using a combination of the actin- and microtubule-based transport systems. However, how these two systems work together to allow well-regulated transport is not clearly understood. We investigate this question in the Xenopus melanophore model system, where three motors, kinesin II, cytoplasmic dynein, and myosin V, drive aggregation or dispersion of pigment organelles called melanosomes. During dispersion, myosin V functions as a “molecular ratchet” to increase outward transport by selectively terminating dynein-driven minus end runs. We show that there is a continual tug-of-war between the actin and microtubule transport systems, but the microtubule motors kinesin II and dynein are likely coordinated. Finally, we find that the transition from dispersion to aggregation increases dynein-mediated motion, decreases myosin V–mediated motion, and does not change kinesin II–dependent motion. Down-regulation of myosin V contributes to aggregation by impairing its ability to effectively compete with movement along microtubules.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
The axonal transport of mitochondria
Hollenbeck, P. J., & Saxton, W. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02745 · Cited by 771
Bidirectional transport along microtubules
Welte, M. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.045 · Cited by 577
Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors
Müller, M. J. I., Klumpp, S., & Lipowsky, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706825105 · Cited by 521
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
Firestone, A. J., Weinger, J. S., Maldonado, M., Barlan, K., Langston, L. D., O’Donnell, M., Gelfand, V. I., Kapoor, T. M., & Chen, J. K. (2012) · Nature · doi:10.1038/nature10936 · Cited by 403
Self-citationComparative Anatomy and Physiology of Pigment Cells in Nonmammalian Tissues
Bagnara, J. T., & Matsumoto, J. (2006) · The Pigmentary System · doi:10.1002/9780470987100.ch2 · Cited by 211
Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles
Encalada, S. E., Szpankowski, L., Xia, C.-H., & Goldstein, L. S. B. (2011) · Cell · doi:10.1016/j.cell.2011.01.021 · Cited by 206
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes
Gibbs, D., Azarian, S. M., Lillo, C., Kitamoto, J., Klomp, A. E., Steel, K. P., Libby, R. T., & Williams, D. S. (2004) · Journal of Cell Science · doi:10.1242/jcs.01580 · Cited by 152
Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation Control Mechanisms
Moreiras, H., Seabra, M. C., & Barral, D. C. (2021) · doi:10.20944/preprints202104.0441.v1 · Cited by 147
Lopes, V. S., Ramalho, J. S., Owen, D. M., Karl, M. O., Strauss, O., Futter, C. E., & Seabra, M. C. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00548.x · Cited by 95
Regulation of microtubule-based transport by MAP4
Semenova, I., Ikeda, K., Resaul, K., Kraikivski, P., Aguiar, M., Gygi, S., Zaliapin, I., Cowan, A., & Rodionov, V. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-01-0022 · Cited by 44
G protein-coupled receptor mediated trimethylamine sensing
Suska, A., Ibáñez, A. B., Lundström, I., & Berghard, A. (2009) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2009.08.012 · Cited by 26
Metadata
- Authors
- Gross, S. P., Tuma, M. C., Deacon, S. W., Serpinskaya, A. S., Reilein, A. R., & Gelfand, V. I.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-02-25
- Volume
- 156
- Issue
- 5
- Pages
- 855-865
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2034725792
- Cited by
- 299
- References
- 0
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
