The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Coordination of opposite-polarity microtubule motors
Open accessAbstract
Many cargoes move bidirectionally, frequently reversing course between plus- and minus-end microtubule travel. For such cargoes, the extent and importance of interactions between the opposite-polarity motors is unknown. In this paper we test whether opposite-polarity motors on lipid droplets in Drosophila embryos are coordinated and avoid interfering with each other's activity, or whether they engage in a tug of war. To this end we impaired the minus-end transport machinery using dynein and dynactin mutations, and then investigated whether plus-end motion was improved or disrupted. We observe a surprisingly severe impairment of plus-end motion due to these alterations of minus-end motor activity. These observations are consistent with a coordination hypothesis, but cannot be easily explained with a tug of war model. Our measurements indicate that dynactin plays a crucial role in the coordination of plus- and minus-end–directed motors. Specifically, we propose that dynactin enables dynein to participate efficiently in bidirectional transport, increasing its ability to stay “on” during minus-end motion and keeping it “off” during plus-end motion.
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Citations
Cites
Dynactin increases the processivity of the cytoplasmic dynein motor
King, S. J., & Schroer, T. A. (2000) · Nature Cell Biology · doi:10.1038/71338 · Cited by 651
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Wu, X., Bowers, B., Rao, K., Wei, Q., & Hammer, J. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.7.1899 · Cited by 418
Developmental Regulation of Vesicle Transport in Drosophila Embryos: Forces and Kinetics
Welte, M. A., Gross, S. P., Postner, M., Block, S. M., & Wieschaus, E. F. (1998) · Cell · doi:10.1016/s0092-8674(00)80947-2 · Cited by 395
Self-citationMartin, M., Iyadurai, S. J., Gassman, A., Gindhart, J. G., Hays, T. S., & Saxton, W. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3717 · Cited by 365
Waterman-Storer, C. M., Karki, S., & Holzbaur, E. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1634 · Cited by 314
Köhrmann, M., Luo, M., Kaether, C., DesGroseillers, L., Dotti, C. G., & Kiebler, M. A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.9.2945 · Cited by 306
Processivity of the Motor Protein Kinesin Requires Two Heads
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Cited by
The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982
Kinesin superfamily motor proteins and intracellular transport
Hirokawa, N., Noda, Y., Tanaka, Y., & Niwa, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2774 · Cited by 1,859
Pilling, A. D., Horiuchi, D., Lively, C. M., & Saxton, W. M. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-06-0526 · Cited by 696
Bidirectional transport along microtubules
Welte, M. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.045 · Cited by 577
Self-citationTug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors
Müller, M. J. I., Klumpp, S., & Lipowsky, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706825105 · Cited by 521
Metadata
- Authors
- Gross, S. P., Welte, M. A., Block, S. M., & Wieschaus, E. F.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-02-28
- Volume
- 156
- Issue
- 4
- Pages
- 715-724
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2010225822
- Cited by
- 280
- References
- 43
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Gross, S. P., Welte, M. A., Block, S. M., & Wieschaus, E. F. (2002). Coordination of opposite-polarity microtubule motors. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200109047
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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