The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Computer simulations reveal motor properties generating stable antiparallel microtubule interactions
Open accessAbstract
An aster of microtubules is a set of flexible polar filaments with dynamic plus ends that irradiate from a common location at which the minus ends of the filaments are found. Processive soluble oligomeric motor complexes can bind simultaneously to two microtubules, and thus exert forces between two asters. Using computer simulations, I have explored systematically the possible steady-state regimes reached by two asters under the action of various kinds of oligomeric motors. As expected, motor complexes can induce the asters to fuse, for example when the complexes consist only of minus end–directed motors, or to fully separate, when the motors are plus end directed. More surprisingly, complexes made of two motors of opposite directionalities can also lead to antiparallel interactions between overlapping microtubules that are stable and sustained, like those seen in mitotic spindle structures. This suggests that such heterocomplexes could have a significant biological role, if they exist in the cell.
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Cites
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Identification of Microtubule Binding Sites in the Ncd Tail Domain
Karabay, A., & Walker, R. A. (1999) · Biochemistry · doi:10.1021/bi981850i · Cited by 82 · cited 1×
“, 1990), but also an additional nonmotor microtubule binding domain (Karabay and Walker, 1999).”
Background
Cited by
Mechanisms for focusing mitotic spindle poles by minus end–directed motor proteins
Goshima, G., Nédélec, F., & Vale, R. D. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505107 · Cited by 259
Self-citationHURP is part of a Ran-dependent complex involved in spindle formation
Koffa, M. D., Casanova, C. M., Santarella, R., Köcher, T., Wilm, M., & Mattaj, I. W. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.056 · Cited by 250
Microtubule organization by the antagonistic mitotic motors kinesin-5 and kinesin-14
Hentrich, C., & Surrey, T. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200910125 · Cited by 167
A Homotetrameric Kinesin-5, KLP61F, Bundles Microtubules and Antagonizes Ncd in Motility Assays
Tao, L., Mogilner, A., Civelekoglu-Scholey, G., Wollman, R., Evans, J., Stahlberg, H., & Scholey, J. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.064 · Cited by 140
MEDYAN: mechanochemical simulations of contraction and polarity alignment in actomyosin networks
Popov, K., Komianos, J., & Papoian, G. A. (2016) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004877 · Cited by 104
Metadata
- Authors
- Nédélec, F.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-09-16
- Volume
- 158
- Issue
- 6
- Pages
- 1005-1015
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2167127135
- Cited by
- 194
- References
- 3
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- green
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