The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Involvement of TRPC in the abnormal calcium influx observed in dystrophic ( mdx ) mouse skeletal muscle fibers
Open accessAbstract
Duchenne muscular dystrophy results from the lack of dystrophin, a cytoskeletal protein associated with the inner surface membrane, in skeletal muscle. The absence of dystrophin induces an abnormal increase of sarcolemmal calcium influx through cationic channels in adult skeletal muscle fibers from dystrophic (mdx) mice. We observed that the activity of these channels was increased after depletion of the stores of calcium with thapsigargin or caffeine. By analogy with the situation observed in nonexcitable cells, we therefore hypothesized that these store-operated channels could belong to the transient receptor potential channel (TRPC) family. We measured the expression of TRPC isoforms in normal and mdx adult skeletal muscles fibers, and among the seven known isoforms, five were detected (TRPC1, 2, 3, 4, and 6) by RT-PCR. Western blot analysis and immunocytochemistry of normal and mdx muscle fibers demonstrated the localization of TRPC1, 4, and 6 proteins at the plasma membrane. Therefore, an antisense strategy was used to repress these TRPC isoforms. In parallel with the repression of the TRPCs, we observed that the occurrence of calcium leak channels was decreased to one tenth of its control value (patch-clamp technique), showing the involvement of TRPC in the abnormal calcium influx observed in dystrophic fibers.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Dystrophin: the protein product of the Duchenne muscular dystrophy locus
Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693
Cited by
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022
Allen, D. G., Whitehead, N. P., & Froehner, S. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00007.2015 · Cited by 426
Effects of stretch‐activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse
Yeung, E. W., Whitehead, N. P., Suchyna, T. M., Gottlieb, P. A., Sachs, F., & Allen, D. G. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.075275 · Cited by 271
Matsuzaka, Y., Tanihata, J., Komaki, H., Ishiyama, A., Oya, Y., Rüegg, U., Takeda, S.-I., & Hashido, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167811 · Cited by 68
Chung, H. S., Kim, G. E., Holewinski, R. J., Venkatraman, V., Zhu, G., Bedja, D., Kass, D. A., & Van Eyk, J. E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712623114 · Cited by 33
Metadata
- Authors
- Vandebrouck, C., Martin, D., Schoor, M. C.-V., Debaix, H., & Gailly, P.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-09-16
- Volume
- 158
- Issue
- 6
- Pages
- 1089-1096
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2000855370
- Cited by
- 344
- References
- 2
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Vandebrouck, C., Martin, D., Schoor, M. C.-V., Debaix, H., & Gailly, P. (2002). Involvement of TRPC in the abnormal calcium influx observed in dystrophic ( mdx ) mouse skeletal muscle fibers. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200203091
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