The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Lineage-specific requirements of β-catenin in neural crest development
Open accessAbstract
β-Catenin plays a pivotal role in cadherin-mediated cell adhesion. Moreover, it is a downstream signaling component of Wnt that controls multiple developmental processes such as cell proliferation, apoptosis, and fate decisions. To study the role of β-catenin in neural crest development, we used the Cre/loxP system to ablate β-catenin specifically in neural crest stem cells. Although several neural crest–derived structures develop normally, mutant animals lack melanocytes and dorsal root ganglia (DRG). In vivo and in vitro analyses revealed that mutant neural crest cells emigrate but fail to generate an early wave of sensory neurogenesis that is normally marked by the transcription factor neurogenin (ngn) 2. This indicates a role of β-catenin in premigratory or early migratory neural crest and points to heterogeneity of neural crest cells at the earliest stages of crest development. In addition, migratory neural crest cells lateral to the neural tube do not aggregate to form DRG and are unable to produce a later wave of sensory neurogenesis usually marked by the transcription factor ngn1. We propose that the requirement of β-catenin for the specification of melanocytes and sensory neuronal lineages reflects roles of β-catenin both in Wnt signaling and in mediating cell–cell interactions.
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Cites
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Cited by
The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells
Hirabayashi, Y., Itoh, Y., Tabata, H., Nakajima, K., Akiyama, T., Masuyama, N., & Gotoh, Y. (2004) · Development · doi:10.1242/dev.01165 · Cited by 600
Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
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Neural crest development is regulated by the transcription factor Sox9
Cheung, M., & Briscoe, J. (2003) · Development · doi:10.1242/dev.00808 · Cited by 482
Pax3 functions at a nodal point in melanocyte stem cell differentiation
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Bone morphogenetic protein signalling and vertebrate nervous system development
Liu, A., & Niswander, L. A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1805 · Cited by 332
Metadata
- Authors
- Hari, L., Brault, V., Kléber, M., Lee, H.-Y., Ille, F., Leimeroth, R., Paratore, C., Suter, U., Kemler, R., & Sommer, L.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2002-12-09
- Volume
- 159
- Issue
- 5
- Pages
- 867-880
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2033032651
- Cited by
- 320
- References
- 65
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Hari, L., Brault, V., Kléber, M., Lee, H.-Y., Ille, F., Leimeroth, R., Paratore, C., Suter, U., Kemler, R., & Sommer, L. (2002). Lineage-specific requirements of β-catenin in neural crest development. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200209039
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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