The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Dynactin is required for bidirectional organelle transport
Open accessAbstract
Kinesin II is a heterotrimeric plus end–directed microtubule motor responsible for the anterograde movement of organelles in various cell types. Despite substantial literature concerning the types of organelles that kinesin II transports, the question of how this motor associates with cargo organelles remains unanswered. To address this question, we have used Xenopus laevis melanophores as a model system. Through analysis of kinesin II–mediated melanosome motility, we have determined that the dynactin complex, known as an anchor for cytoplasmic dynein, also links kinesin II to organelles. Biochemical data demonstrates that the putative cargo-binding subunit of Xenopus kinesin II, Xenopus kinesin II–associated protein (XKAP), binds directly to the p150Glued subunit of dynactin. This interaction occurs through aa 530–793 of XKAP and aa 600–811 of p150Glued. These results reveal that dynactin is required for transport activity of microtubule motors of opposite polarity, cytoplasmic dynein and kinesin II, and may provide a new mechanism to coordinate their activities.
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Dynactin increases the processivity of the cytoplasmic dynein motor
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The Molecular Motor Toolbox for Intracellular Transport
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Bidirectional transport along microtubules
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Metadata
- Authors
- Deacon, S. W., Serpinskaya, A. S., Vaughan, P. S., Fanarraga, M. L., Vernos, I., Vaughan, K. T., & Gelfand, V. I.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-01-27
- Volume
- 160
- Issue
- 3
- Pages
- 297-301
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1989370009
- Cited by
- 311
- References
- 43
- FWCI
- 11.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Deacon, S. W., Serpinskaya, A. S., Vaughan, P. S., Fanarraga, M. L., Vernos, I., Vaughan, K. T., & Gelfand, V. I. (2003). Dynactin is required for bidirectional organelle transport. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200210066
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
