The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ
Open accessAbstract
Clathrin-mediated endocytosis of synaptic vesicle membranes involves the recruitment of clathrin and AP-2 adaptor complexes to the presynaptic plasma membrane. Phosphoinositides have been implicated in nucleating coat assembly by directly binding to several endocytotic proteins including AP-2 and AP180. Here, we show that the stimulatory effect of ATP and GTPγS on clathrin coat recruitment is mediated at least in part by increased levels of PIP2. We also provide evidence for a role of ADP-ribosylation factor 6 (ARF6) via direct stimulation of a synaptically enriched phosphatidylinositol 4-phosphate 5-kinase type Iγ (PIPKIγ), in this effect. These data suggest a model according to which activation of PIPKIγ by ARF6-GTP facilitates clathrin-coated pit assembly at the synapse.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Role of the ENTH Domain in Phosphatidylinositol-4,5-Bisphosphate Binding and Endocytosis
Itoh, T., Koshiba, S., Kigawa, T., Kikuchi, A., Yokoyama, S., & Takenawa, T. (2001) · Science · doi:10.1126/science.291.5506.1047 · Cited by 469
Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions
Ling, K., Doughman, R. L., Firestone, A. J., Bunce, M. W., & Anderson, R. A. (2002) · Nature · doi:10.1038/nature01082 · Cited by 443
Di Paolo, G., Pellegrini, L., Letinic, K., Cestra, G., Zoncu, R., Voronov, S., Chang, S., Guo, J., Wenk, M. R., & De Camilli, P. (2002) · Nature · doi:10.1038/nature01147 · Cited by 441
Self-citationShupliakov, O., Bloom, O., Gustafsson, J. S., Kjaerulff, O., Löw, P., Tomilin, N., Pieribone, V. A., Greengard, P., & Brodin, L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212381799 · Cited by 247
Kim, W. T., Chang, S., Daniell, L., Cremona, O., Di Paolo, G., & De Camilli, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222657399 · Cited by 123
Cited by
Maxfield, F. R., & McGraw, T. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1315 · Cited by 1,729
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Regulation of AMPA receptor trafficking and synaptic plasticity
Anggono, V., & Huganir, R. L. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.12.006 · Cited by 588
Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane
Ono, A., Ablan, S. D., Lockett, S. J., Nagashima, K., & Freed, E. O. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405596101 · Cited by 553
Localization and function of Arf family GTPases
Donaldson, J. G., & Honda, A. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330639 · Cited by 170
Metadata
- Authors
- Krauss, M., Kinuta, M., Wenk, M. R., De Camilli, P., Takei, K., & Haucke, V.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2003-07-07
- Volume
- 162
- Issue
- 1
- Pages
- 113-124
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2155151508
- Cited by
- 286
- References
- 5
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ. https://app.cochat.ai/papers/10.1083/jcb.200301006
- The paper
- Krauss, M., Kinuta, M., Wenk, M. R., De Camilli, P., Takei, K., & Haucke, V. (2003). ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Iγ. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200301006
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
