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The Drosophila pericentrin-like protein is essential for cilia/flagella function, but appears to be dispensable for mitosis
Open accessAbstract
Centrosomes consist of a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Proteins that contain a Pericentrin/AKAP450 centrosomal targeting (PACT) domain have been implicated in recruiting several proteins to the PCM. We show that the only PACT domain protein in Drosophila (the Drosophila pericentrin-like protein [D-PLP]) is associated with both the centrioles and the PCM, and is essential for the efficient centrosomal recruitment of all six PCM components that we tested. Surprisingly, however, all six PCM components are eventually recruited to centrosomes during mitosis in d-plp mutant cells, and mitosis is not dramatically perturbed. Although viable, d-plp mutant flies are severely uncoordinated, a phenotype usually associated with defects in mechanosensory neuron function. We show that the sensory cilia of these neurons are malformed and the neurons are nonfunctional in d-plp mutants. Moreover, the flagella in mutant sperm are nonmotile. Thus, D-PLP is essential for the formation of functional cilia and flagella in flies.
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Cited by
Basto, R., Lau, J., Vinogradova, T., Gardiol, A., Woods, C. G., Khodjakov, A., & Raff, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.05.025 · Cited by 686
Self-citationSAK/PLK4 Is Required for Centriole Duplication and Flagella Development
Bettencourt-Dias, M., Rodrigues-Martins, A., Carpenter, L., Riparbelli, M., Lehmann, L., Gatt, M. K., Carmo, N., Balloux, F., Callaini, G., & Glover, D. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.11.042 · Cited by 600
Asymmetric Inheritance of Mother Versus Daughter Centrosome in Stem Cell Division
Yamashita, Y. M., Mahowald, A. P., Perlin, J. R., & Fuller, M. T. (2007) · Science · doi:10.1126/science.1134910 · Cited by 560
Centrosome Amplification Can Initiate Tumorigenesis in Flies
Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A., & Raff, J. W. (2008) · Cell · doi:10.1016/j.cell.2008.05.039 · Cited by 560
Self-citationBug22 influences cilium morphology and the post-translational modification of ciliary microtubules
Mendes Maia, T., Gogendeau, D., Pennetier, C., Janke, C., & Basto, R. (2014) · Biology Open · doi:10.1242/bio.20146577 · Cited by 47
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Metadata
- Authors
- Martinez-Campos, M., Basto, R., Baker, J., Kernan, M., & Raff, J. W.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-06-07
- Volume
- 165
- Issue
- 5
- Pages
- 673-683
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2170163976
- Cited by
- 255
- References
- 0
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Martinez-Campos, M., Basto, R., Baker, J., Kernan, M., & Raff, J. W. (2004). The Drosophila pericentrin-like protein is essential for cilia/flagella function, but appears to be dispensable for mitosis. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200402130
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