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Borealin
Open accessAbstract
The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Here, we describe Borealin, a novel member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin; and Borealin binds Survivin and INCENP in vitro. A second complex contains Aurora B and INCENP, but no Borealin or Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore–spindle misattachments and an increase in bipolar spindles associated with ectopic asters. The extra poles, which apparently form after chromosomes achieve a bipolar orientation, severely disrupt the partitioning of chromosomes in anaphase. Borealin depletion has little effect on histone H3 serine10 phosphorylation. These results implicate the chromosomal passenger holocomplex in the maintenance of spindle integrity and suggest that histone H3 serine10 phosphorylation is performed by an Aurora B–INCENP subcomplex.
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Citations
Cited by
Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation
Kurasawa, Y., Earnshaw, W. C., Mochizuki, Y., Dohmae, N., & Todokoro, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600347 · Cited by 333
Self-citationMps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
Jelluma, N., Brenkman, A. B., van den Broek, N. J. F., Cruijsen, C. W. A., van Osch, M. H. J., Lens, S. M. A., Medema, R. H., & Kops, G. J. P. L. (2008) · Cell · doi:10.1016/j.cell.2007.11.046 · Cited by 294
The chromosomal passenger complex: guiding Aurora-B through mitosis
Vader, G., Medema, R. H., & Lens, S. M. A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200604032 · Cited by 299
ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy
Maskey, D., Yousefi, S., Schmid, I., Zlobec, I., Perren, A., Friis, R., & Simon, H.-U. (2013) · Nature Communications · doi:10.1038/ncomms3130 · Cited by 144
Disorders of thyroid morphogenesis
Abu-Khudir, R., Larrivée-Vanier, S., Wasserman, J. D., & Deladoëy, J. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.04.008 · Cited by 46
Metadata
- Authors
- Gassmann, R., Carvalho, A., Henzing, A. J., Ruchaud, S., Hudson, D. F., Honda, R., Nigg, E. A., Gerloff, D. L., & Earnshaw, W. C.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-07-12
- Volume
- 166
- Issue
- 2
- Pages
- 179-191
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2002125670
- Cited by
- 440
- References
- 0
- FWCI
- 15.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gassmann, R., Carvalho, A., Henzing, A. J., Ruchaud, S., Hudson, D. F., Honda, R., Nigg, E. A., Gerloff, D. L., & Earnshaw, W. C. (2004). Borealin. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200404001
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