The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling
Open accessAbstract
Yeast cells can initiate bud formation at the G1/S transition in a cue-independent manner. Here, we investigate the dynamic nature of the polar cap and the regulation of the GTPase Cdc42 in the establishment of cell polarity. Using analysis of fluorescence recovery after photobleaching, we found that Cdc42 exchanged rapidly between the polar caps and cytosol and that this rapid exchange required its GTPase cycle. A previously proposed positive feedback loop involving actomyosin-based transport of the Cdc42 GTPase is required for the generation of robust cell polarity during bud formation in yeast. Inhibition of actin-based transport resulted in unstable Cdc42 polar caps. Unstable polarity was also observed in mutants lacking Bem1, a protein previously implicated in a feedback loop for Cdc42 activation through a signaling pathway. When Bem1 and actin were both inhibited, polarization completely failed. These results suggest that cell polarity is established through coupling of transport and signaling pathways and maintained actively by balance of flux.
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Citations
Cites
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Joberty, G., Petersen, C., Gao, L., & Macara, I. G. (2000) · Nature Cell Biology · doi:10.1038/35019573 · Cited by 928 · cited 1×
“We speculate that Bem1 is a functional analogue of the metazoan protein Par6, which binds activated Cdc42 and mediates the cooperative assembly of a multi-functional polarity complex (Joberty et al., 2000; Fukata et al., 2003; Garrard et al., 2003).”
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Cited by
Interlinked Fast and Slow Positive Feedback Loops Drive Reliable Cell Decisions
Brandman, O., Ferrell, J. E., Li, R., & Meyer, T. (2005) · Science · doi:10.1126/science.1113834 · Cited by 466
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Metadata
- Authors
- Wedlich-Soldner, R., Wai, S. C., Schmidt, T., & Li, R.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2004-09-07
- Volume
- 166
- Issue
- 6
- Pages
- 889-900
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2125808663
- Cited by
- 220
- References
- 1
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Wedlich-Soldner, R., Wai, S. C., Schmidt, T., & Li, R. (2004). Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200405061
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