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Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1–Cdk1 at the centrosome
Open accessAbstract
Cdc25 phosphatases are essential for the activation of mitotic cyclin–Cdks, but the precise roles of the three mammalian isoforms (A, B, and C) are unclear. Using RNA interference to reduce the expression of each Cdc25 isoform in HeLa and HEK293 cells, we observed that Cdc25A and -B are both needed for mitotic entry, whereas Cdc25C alone cannot induce mitosis. We found that the G2 delay caused by small interfering RNA to Cdc25A or -B was accompanied by reduced activities of both cyclin B1–Cdk1 and cyclin A–Cdk2 complexes and a delayed accumulation of cyclin B1 protein. Further, three-dimensional time-lapse microscopy and quantification of Cdk1 phosphorylation versus cyclin B1 levels in individual cells revealed that Cdc25A and -B exert specific functions in the initiation of mitosis: Cdc25A may play a role in chromatin condensation, whereas Cdc25B specifically activates cyclin B1–Cdk1 on centrosomes.
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Cites
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
Sage, J., Miller, A. L., Pérez-Mancera, P. A., Wysocki, J. M., & Jacks, T. (2003) · Nature · doi:10.1038/nature01764 · Cited by 538
Cited by
The Aurora kinase family in cell division and cancer
Vader, G., & Lens, S. M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.003 · Cited by 417
The when and wheres of CDC25 phosphatases
Boutros, R., Dozier, C., & Ducommun, B. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.02.003 · Cited by 414
Cdc25: mechanisms of checkpoint inhibition and recovery
Karlsson-Rosenthal, C., & Millar, J. B. A. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.04.002 · Cited by 276
Lossaint, G., Besnard, E., Fisher, D., Piette, J., & Dulić, V (2011) · Oncogene · doi:10.1038/onc.2011.135 · Cited by 83
Metadata
- Authors
- Lindqvist, A., Källström, H., Lundgren, A., Barsoum, E., & Rosenthal, C. K.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2005-10-10
- Volume
- 171
- Issue
- 1
- Pages
- 35-45
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2126150038
- Cited by
- 200
- References
- 1
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Lindqvist, A., Källström, H., Lundgren, A., Barsoum, E., & Rosenthal, C. K. (2005). Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1–Cdk1 at the centrosome. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200503066
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