The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes
Open accessAbstract
Spindle formation is essential for stable inheritance of genetic material. Experiments in various systems indicate that Ran GTPase is crucial for meiotic and mitotic spindle assembly. Such an important role for Ran in chromatin-induced spindle assembly was initially demonstrated in Xenopus laevis egg extracts. However, the requirement of RanGTP in living meiotic cells has not been shown. In this study, we used a fluorescence resonance energy transfer probe to measure RanGTP-regulated release of importin β. A RanGTP-regulated gradient was established during meiosis I and was centered on chromosomes throughout mouse meiotic maturation. Manipulating levels of RanGTP in mice and X. laevis oocytes did not inhibit assembly of functional meiosis I spindles. However, meiosis II spindle assembly did not tolerate changes in the level of RanGTP in both species. These findings suggest that a mechanism common to vertebrates promotes meiosis I spindle formation in the absence of chromatin-induced microtubule production and centriole-based microtubule organizing centers.
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Silljé, H. H. W., Nagel, S., Körner, R., & Nigg, E. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.070 · Cited by 267
HURP is part of a Ran-dependent complex involved in spindle formation
Koffa, M. D., Casanova, C. M., Santarella, R., Köcher, T., Wilm, M., & Mattaj, I. W. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.056 · Cited by 250
Cited by
Holubcová, Z., Blayney, M., Elder, K., & Schuh, M. (2015) · Science · doi:10.1126/science.aaa9529 · Cited by 324
The RanGTP gradient—a GPS for the mitotic spindle
Kalab, P., & Heald, R. (2008) · Journal of Cell Science · doi:10.1242/jcs.005959 · Cited by 293
Metadata
- Authors
- Dumont, J., Petri, S., Pellegrin, F., Terret, M.-E., Bohnsack, M. T., Rassinier, P., Georget, V., Kalab, P., Gruss, O. J., & Verlhac, M.-H.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-01-29
- Volume
- 176
- Issue
- 3
- Pages
- 295-305
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2080280371
- Cited by
- 243
- References
- 2
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Dumont, J., Petri, S., Pellegrin, F., Terret, M.-E., Bohnsack, M. T., Rassinier, P., Georget, V., Kalab, P., Gruss, O. J., & Verlhac, M.-H. (2007). A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes. The Journal of Cell Biology. https://doi.org/10.1083/jcb.200605199
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
